pathology of the stomach Flashcards
name 3 inflammatory disorders of the stomach
acute gastritis
chronic gastritis
rare: lymphocytic, granulomatous, osinophillic
what can cause acute gastritis?
arritant chemical injury severe burns shock severe trauma head injury
what can casue chronic gastritis?
autoimmune
bacterial
chemical
what dos autoimmune chronic gastritis do?
due to immune system prodicing antibodies against own stomach lining (parietal cells) causing atrophy
what can autoimmune chronic gastritis cause?
atrophy and intestinal metaplasia in body of stomach
pernicious anaemia, macrocytic due to B12 deficiency
increased risk of malignancy
SACD
what are the symptoms of autoimmune chronic gastritis?
tiredness
staggering gate
what is the most common type of chronic gastritis?
H. pylori associated
what happens in H. pylori chronic gastritis?
bacteria inhibits a niche between epithelial cel surface and mucous barrier
Excites early acute inflammatory response
If not cleared then a chronic active inflammation
ensues
IL8 is involved
what type of bacteria is H. pylori?
gram -ve curvilinear rod
what can H. pylori associated chronic gastritis increase the risk of?
Lamina propria plasma cells produce anti H.pylori antibodies
Increases risk of Duodenal ulcer
Increases risk of Gastric Ulcer
Increases risk of Gastric carcinoma
Increases risk of Gastric lymphoma
do the H. pylori invade the stomach?
no, just sit and irritate the epithelium
what can cause chemical gastritis?
NSAIDs
alcohol
bile reflux
direct injury to mucous layer by fat solvents
how does injury to mucous layer by fat solvents cause chemical gastritis?
Marked epithelial regeneration, hyperplasia, congestion and little inflammation
May produce erosions or ulcers
what does chemical gastritis look like?
red with lots of lesions
what is peptic ulceration?
a breach in the gastrointestinal mucosa as a result of acid and pepsin attack
a discontinuity in epithelial surface?
tend to be chronic an deep