Biliary Tract Disease Flashcards

1
Q

what are the 2 main biliary tract diseases?

A

gallstones

biliary tract cancer

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2
Q

what are the symptoms of gallstones?

A
Most are asymptomatic
colic
cholecystitis
jaundice
pancreatitis
bowel obstruction
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3
Q

what are the symptoms of gallstones?

A
Most are asymptomatic
biliary colic
cholecystitis
jaundice
pancreatitis
bowel obstruction
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4
Q

what can cause gallstones?

A
abnormal bile composition
bile stasis
infection
excess cholesterol
excess bilirubin
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5
Q

what are the components of bile?

A

cholesterol
bilirubin
phospholipids
sodium and potassium

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6
Q

what type of gallstones are most common?

A

mixed (80%)
cholesterol (10%)
biliruvin (10%)

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7
Q

name some risk factors for gallstones?

A
fat
female
40s or over
fertile
foetus
(4 Fs)
bile salt loss (crohns)
diabetes
dysmobility of GB
prolonged fasting
TPN (total parenteral nutrition)
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8
Q

how can gallstones cause a fistula?

A

continuous inflammation of the gall bladder wall (in close association to duodenum) can cause a fistula to form

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9
Q

what is bilary colic?

A

where 1 big stone gets stuck leaving the gall bladder

causes severe pain and spasm

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10
Q

how can a gallstone cause acute cholecystitis?

A

stone stuck in the neck causes obstruction
cause increased pressure on the walls
can cause distension, infection and sever pain

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11
Q

what does an air fluid level in gallbladder in XR suggest?

A

gas within the gallbladder - possible duodenal fistula

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12
Q

how can gallstones be diagnosed?

A
US (best, 1st line)
CT scan (only to assess complications)
MRCP/ERCP
HIDA (nuclear test, looks at motility)
EUS
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13
Q

how is acute cholecystitis treated?

A

IV antibiotics + IV fluids
nil by mouth
urgent or interval cholecystectomy

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14
Q

how is acute cholecystitis treated?

A

IV antibiotics + IV fluids
nil by mouth
urgent(2-5 days) or interval cholecystectomy (several weeks, inflammation died down)

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15
Q

what can occur when gallstones migrate into common bile duct?

A

jaundice
cholangitis
acute pancreatitis (gets stuck at ampulla where pancreatic duct joins)

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16
Q

what is gallstone ileus?

A

obstruction of the bowel by gallstone impacted in distal ileum

17
Q

what are the symptoms of common bile duct pathology?

A
itch
nausea
anorexia
jaundice
abnormal LFTs
18
Q

what is ERCP mainly used for, imaging or treatment?

A

treatment

removal of stones

19
Q

what are the most common causes of pancreatitis?

A

alcohol

gallstones

20
Q

how do gallstones cause acute pancreatitis?

A

obstruct ampulla of vater to pancreatic duct is blocked and enzymes back up into pancreas causing autodigestion of pancreas

21
Q

how does gallstone ileus occur?

A

fistula between gallbladder and duodenum
gallstone passes into small intestine
Moves down small bowel causing intermittent colic
present with distal small bowel obstruction

22
Q

how is gallstone ileus treated?

A

urgent laparotomy - small bowel enterectomy to remove stone

Interval cholecystectomy if needed

23
Q

what is cholangiocarcinoma?

A

cancer of the bile duct

2nd most common hepatobiliary cancer

24
Q

how does cholangiocarcinoma present?

A

jaundice (late sign - probably spread)
weight loss
anorexia
lethargy

25
Q

how is cholangiocarcinoma staged?

A

duplex US
spiral CT/ERCP/PTC)
MRI/MRCP/MRA

26
Q

what are the 4 types of cholangiocarcnoma?

A
I = just below hila
II = confined to confluence of biliary tree
IIIa = into right hepatic duct
IIIb = into left hepatic duct
IV = into right and left duct
27
Q

what is the only chance of cure of cholangiocarcinoma?

A

surgical resection

28
Q

how is cholangiocarcnoma treated palliatively?

A

biliary stent (ERC/PTC stent insertion)