Pathology of the Colorectal Carcinoma Flashcards
polyp
profusion above an epithelial surface
tumour (swelling)
differential diagnosis of a colonic polyp
adenoma
serrated ployp
polypoid carcinoma
other
types of ployp
pedunculated
sessile
flat
most polyps are adenomas
tubullovillous
villous
tubular
all are dysplastic
adenoma-carcinoma sequence
normal mucosa - adenoma (dysplastic) - adenocarcinoma (invasive)
colorectal carcinoma
dukes a - confined by muscular proproa
dukes b - through muscularis propria
dukes c - metastatic to lymph nodes
colorectal carcinoma - left side
blood PR
altered bowel habit
obstruction
colorectal carcinoma - right side
anaemia
weight loss
diverticular disease
common
asymptomatic
related to low fibre diet and increased intralumenal pressure
leads to herniation through the membrane
diverticulum
an abnormal sac or pouch formed at a weak point in the wall of the alimentary tract
diverticular disease - complications
inflammation rupture abscess fistula massive bleeding
ischaemia of the large bowl
old people disease - caused by atherosclerosis
left sided disease
pseudomembranous colitis
antibiotic-induced
can get it on chemo
anything that kills bacteria
collagenous colitis
thickened basement membrane
normal is between 2-3 microns
disease is patchy
associated with intraepithelial inflammatory cells
radiation colitis
chronic active or inactive colitis
telangectasia
bizarre stromal cells, bizarre vessels
may be other complications of immunosuppression if also on chemo
consequence of radiotherapy