Pathology of IBD

Question 1

Define Crohn’s disease?

Answer 1

Chronic inflammaotry and ulcerative condition of the GI tract that can affect anywhere between mout-anus

Transmural inflammation which can affect all layers of the GI lining

Question 2

Which sites of the body are affected by Crohn’s?

Answer 2

1. Small bowel- most commonly the ileum
2. 1/6 have colonic/ anal disease
3. Both
4. Stmoach, oesophagus, mouth

Question 3

What is the common histological presentation of Crohn’s? (hint-skip)

Answer 3

Skip lesions- Patchy areas of inflmamation along with patchy areas of normal mucosa.

Not continuous inflammation

Question 4

In Crohn’s patchy chronic inflammation can be present with numerous Granulomas. T/F?

Answer 4

True

Question 5

Patchy chronic active colitis

Question 6

Summarise the pathologial changes seen in Crohn’s.

Answer 6

1. •Segmental disease (patchy)

•

•Ileal and/or colonic chronic active mucosal inflammation including:

• Cryptitis
• Crypt abscesses

•

•Transmural inflammation

•

•Deep knife-like fissuring ulcers

•

•Granulomas, 50%, Non- caseating

Question 7

Why can Crohn’s lead to Malabsorption?

Answer 7

Short bowel syndrome- due to recurrences and repeated resections.

Question 8

What are the complications of Chron’s?

Question 9

UC is a chronic inflammatory disease mostly confined to the _ and _

Answer 9

Colon and rectum- mucosal and submucosal inflammatio

Question 10

Inflammation in UC is continuous unlike in Chrons’s. T/F?

Answer 10

True

Question 11

Define the pathological changes in UC?

Answer 11

1. Continous, diffuse inflammation
2. Almost Always Rectal involvement
3. Superficial Ulceration + Inflammation
4. Chronic active Colitis- Cryptitis, Crypt abscess
5. No granulomas

Question 12

What is toxic megacolon?

Answer 12

Acute or acute on chronic fulminant colitis. Colon swells up to massive size. Will rupture unless removed