Pathology - Inflammation 2 Flashcards
What are the 4 possibilities after a response to an infection?
Resolution, suppuration, repair, organisation and fibrosis or chronic inflammation. Often is a combination. Slide 6
The outcomes of a response to infection depends on what?
Site of injury (capacity of repair), type of injury (severity) and duration of injury (is it sustained). Slide 8
What is resolution?
Complete restoration of tissue as there is minimal cell death, has a good vascular supply so efficient delivery of WBC to remove pathogens rapidly. Slide 9 + 10
What is suppuration?
Pus containing living, dead cells, neutrophils and bacteria. Slide 12
Do antibiotics work for suppuration and why?
No, because there is no blood supply to the area, can’t reach site. Slide 12
What is an empyema?
A spaces walled off, and is filled with pus, e.g. the Gallbladder. Slide 12
What is repair and organisation?
Essentially scarring with lots of fibrin. Slide 14
When does repair and organisation occur?
When damage goes beyond the basement membrane. This can be by a lot of necrosis, lots of fibrin that isn’t easily cleared, poor blood supply and tissue type as some can regenerate. Slide 14
What is the common response in all tissues when healing?
Granulation tissue formation. Slide 19
What is granulation tissue and how is it formed?
Very slow to form and new blood vessels are made. Collagen and smooth muscle cells are deposited and looks very red. Slide 20
What is scarring and fibrosis?
Patch job and causes a loss of function. E.g. in the heart, it wouldn’t contract as well. Slide 24
What is cirrhosis of the liver?
Scarring and fibrosis of the liver and results in loss of liver function meaning there is vascular disturbances due to the large volume of blood that flows through it. Slide 25
When is chronic inflammation favoured?
Suppuration, persistence of injury, infectious agent and type of injury. Slide 29
How is chronic inflammation characterised?
By the lymphocyte and other cells e.g. macrophage. Slide 30
What is a granuloma?
An aggregate of epithelioid histiocytes. Slide 32
