Pathology

Question 1

Define:
Hyperkeratosis
Parakeratosis
Acanthiosis 
Papillomatosis
Spongiosis

Answer 1

Hyper - increased thickness of keratin
Parakeratosis - persistence of nuclei in keratin layer
Acanthosis - increased thickness of epithelium
Papillomatosis - irregular epithelial thickening
Spongiosis - oedema fluid between squamous - increase prominence of intercellular prickles

Question 2

Classification of inflammatory skin diseases

Answer 2

Spongiotic-intraepidermal oedema e.g. eczema
Psoriasifrom-elongation of the rate ridges e.g. psoriasis
Lichenoid-basal layer damage e.g. lichen plants
Vesiculobullous-blistering

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Question 3

Psoriasis

Answer 3

Elongated and lumped dermis
Common
partly herideratry

Question 4

Lichenoid-basal layer

Answer 4

Flat topped
Virulanoeus???
Itchy

Question 5

Lichen planus

Answer 5

Irregular sawtooth acanthosis

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Question 6

Colloid/cytoid bodies

Answer 6

At dermal-epidermal junction

Question 7

Immunobullous diseases

Answer 7

Blisters are the primary feature

Break down of desmosomes

Question 8

What causes pemphigus?

Answer 8

Acanthiolysis - lysis of desmosomes holding

Question 9

Difference between bullous pemihigoid and pemphigus vulgaris?

Answer 9

Pemphigus vulgaris - acanthiolysis

Bullous pemphigoid - no acanthiolysis

Question 10

What causes bullous pemphigoid?

Answer 10

Autoimmune attack on dermal-epidermal junctions

double check

Question 11

What skin condition is associated with coeliac disease/

Answer 11

Dermatitis herpetiformis

- itchy knees, elbows and buttocks

Question 12

How is acne caused?

Answer 12

Plugging
Cystic distension
Rupture with some fibrosis

Question 13

Rosacea

Answer 13

Demodex lives in rosacea

Question 14

Proliferation of suprabasal cells cause what kind of lesion?

Answer 14

Scaly/crusty

Question 15

What is a dermafibrolast?

Answer 15

Proliferation of dermal????