Bullous Disorders Flashcards
For each of the following criteria, describe the differences/similarities between bullous pemphigoid and pemphigus vulgaris:
- tense or flaccid bullae
- location
- Nikolsky sign
- mucosal involvement?
- layer of split
Bullous pemphigoid
- tense bullae
- trunk + proximal limbs
- Nikolsky sign -ve
- rare for mucosal involvement
- affects DEJ (pemphigoiD = Deeper)
Pemphigus vulgaris
- flaccid bullae
- head, scalp, axillae, groin
- common for mucosal involvement
- intra-epidermal (pemphiguS = Superficial)
How are bullous conditions diagnosed?
Skin biopsy with immunofluorescence
Who most commonly presents with bullous pemphigoid?
Elderly people (over 70s)
How are bullous conditions managed?
Systemic steroids (prednisolone) \+ topical treatment
What is Nikolsky sign?
What does it indicate?
Top layer of skin slips away from lower layers when slightly rubbed
Plane of cleavage within the epidermis
What type of blistering disease is caused by an autoimmune reaction to desmosomes?
Pemphigus vulgaris
Paitent presents with blistering inside of mouth and other mucosal linings.
What type is it more likely to be?
Pemphigus vulgaris
In what condition are hemidesmosomes affected?
Bullous pempigoid
