Pathology Flashcards
Etiology
Cause of disease
Pathogenesis
Mechanisms of disease development
Morphologic changes
Structural alterations induced in cells and organs
Clinical manifestations
Functional consequences of morphologic changes
Classes of etiology
Genetic and acquired
Pathogenesis
Sequence of events after exposure to an injurious agent (disease)
Symptom
Problems experienced by the patient
Sign
Abnormality discovered during an examination by a clinician
What type of cell components have an affinity for basic dyes?
Anionic components (nucleic acids)
What cell components have an affinity for acidic dyes?
Cationic components
Hematoxylin is a _____ dye and stains _____ components a _____ color.
Basic, anionic, blue/purple
Eosin is a _____ dye and stains _____ components a _____ color.
Acidic, cationic, pink
What histology staining is used most commonly?
Hematoxylin and eosin combination (H&E)
Periodic-acid-Schiff (PAS) rxn
Carb-rich tissue structures and stains them purple/magenta
Trichromatic stains show distinctions among what kind of components?
Extracellular tissue components (collagen)
Trichromatic stains result in what colorings?
Nuclei-purple
Cytoplasm, keratin, and erythrocytes-bright red/orange
Collagen-bright/light blue
Metal impregnating demonstrates what structures?
Filamentous structures in neurons and fibers of reticulin (type III collagen)
What stains can be used to distinguish between elastic structures and collagen?
Weigert’s resorcin fuchsin, aldehyde fuchsin, and orcein
Wright-Giemsa Stain is used on what tissues?
Blood or bone marrow to demonstrate types of blood cells
What does Perls’ Prussian blue rxn stain for?
Iron
Immunohistochemistry is used to identify what type of macromolecules?
Proteins
Cytology
Studies and diagnoses disease on the cellular level
How are cells collected for cytology?
Spontaneous exfoliation, mechanical exfoliation, or fine needle aspiration
