Complement

Question 1

Complement proteins C5-9

Answer 1

Membrane Attack Complex

Question 2

Complement proteins what promote inflammation

Answer 2

C3a, C4a, C5a

Question 3

Opsonizing Complement proteins

Answer 3

C3b

Question 4

Complement receptor I

Answer 4

Binds C3b

Question 5

Activating Step: Alternative pathway

Answer 5

Random binding of C3 on the surface of a microbe

Question 6

Activating step: Classical Pathway

Answer 6

IgG antibody binds to microbe surface, creating the C1 complex which activates C4 and C2.

Question 7

Activating step: Lectin Pathway

Answer 7

Mannose binding lectin binds to mannose on microbe surface, activating C4 and C2

Question 8

C3 Convertase: Alternative pathway

Answer 8

C3bBb

Question 9

C3 Convertase: Classical and Lectin pathway

Answer 9

C4b2a

Question 10

C5 Convertase: Alternative pathway

Answer 10

C3bBbC3b

Question 11

C5 Convertase: Classical and Lectin Pathway

Answer 11

C4b2aC3b

Question 12

Complement protein that promotes antibody production

Answer 12

C3d which is recognized by CR2 on B cells stimulating B cell production of antibodies.

Question 13

C1 inhibitor

Answer 13

Inhibits C1r and C1s serine proteases

Question 14

Factor I

Answer 14

Cleaves C3b and C4b

Question 15

Factor H

Answer 15

Dissociates C3C in classical pathway

Question 16

C4 binding protein

Answer 16

Dissociates C3C in classical pathway

Question 17

Membrane Cofactor Protein

Answer 17

Cofactor to Factor I

Question 18

Decay Accelerating factor

Answer 18

blocks C3C from forming

Question 19

CD59

Answer 19

Blocks C9 dimerization

Question 20

Type 1 complement receptor

Answer 20

Dissociated C3C

Question 21

Hereditary angioedema

Answer 21

C1 inhibitor deficiency, leads to increased C4 protein and increased bradykinin

Question 22

Paroxsymal nocturnal hemoglobinuria

Answer 22

DAF and CD59 deficiency

Question 23

Deficiencies in C1-4

Answer 23

Can lead to recurrent bacterial infections and immune complex diseases like SLE

Question 24

Deficiencies in C5-9

Answer 24

Can lead to recurrent meningococcal and gonococcal infections.

Question 25

Omenn Syndrome

Answer 25

RAG enzymes only partially active. 
Lack of or very few B cells
Failure to Thrive
Erythroderma
Diarrhea
Severe immunodeficiency

Question 26

Severe Combine Immunodeficiency (SCID)

Answer 26

Complete lack of RAG activity
Total lack of B and T cells
Interstitial lung disease
Diarrhea
Failure to thrive
Severe recurrent infections