Pathology 1

Question 1

XXY, testicular atrophy, eunuchoid body shape, tall, long extremities, gynecomastia

Answer 1

Klinefelter Syndrome

Question 2

Heart anomaly of Turner Syndrome

Answer 2

Bicuspid aortic valve; preductal coarctation

Question 3

Webbed neck or cystic hygroma

Answer 3

Turner Syndrome (XO)

Question 4

Most common cause of Primary amenorrhea

Answer 4

Turner Syndrome (XO)

Question 5

Kidney problems associated with Turner Syndrome

Answer 5

Horseshoe Kidney

Question 6

Pregnancy in Turner Syndrome

Answer 6

need oocyte donation, exogenous estradiol-17beta and progesterone

Question 7

Phenotypically normal, very tall, severe acne, antisocial behavior; Normal fertility; Men

Answer 7

XYY

Question 8

Both ovary and testicular tissue present; ambiguous genitalia

Answer 8

True hermaphroditism (46, XX or 47,XXY)

Question 9

Increase in both Testosterone and LH

Answer 9

Defective androgen receptor

Question 10

Increase in Testosterone and decrease LH

Answer 10

Testosterone-secreting tumor, exogenous steroids

Question 11

Decrease in Testosterone and increase LH

Answer 11

Primary hypogonadism

Question 12

Decrease in both Testosterone and LH

Answer 12

Hypogonadotropic Hypogonadism

Question 13

Ovaries present, but external genitalia are virilized or ambiguous. Excessive and inappropriate exposure to androgenic steroids during early gestation

Answer 13

Femal pseudohermaphrodite (XX)

Question 14

Testes present, external genitalia are female or ambiguous. Most common form is androgen insensitivity syndrome (testicular feminization)

Answer 14

Male pseudohermaphrodite (XY)

Question 15

Inability to synthesize estrogens from androgens. Masculinization of female infants and increase serum testosterone and androstenedione.

Answer 15

Aromatase Deficiency

Question 16

Defect in androgen receptor resulting in normal-appearingfemale; female external genitalia with rudimentary vagina; uterus and fallopian tubes generally absent

Answer 16

Androgen Insensitivity Syndrome (46, XY)

Question 17

Inability to convert testosterone to DHT. Ambiguous genitalia until puberty, when increase testosterone causes masculinization/increase growth of external genitalia; testosterone/estrogen levels are normal

Answer 17

5alpha-reductase deficiency

Question 18

Failure of complete puberty; a form of hypogonadotropic hypogonadism. Defective migration of GnRH cells and formation of olfactory bulb; anosmia & infertility

Answer 18

Kallmann Syndrome

Question 19

Fetal Parts

Answer 19

Partial Hydatidiform Mole, low hCG, 2sperm +1egg

69XXX, XXY, XYY

Question 20

Incredibly high hCG, increased uterine size, Honeycombed uterus or “clusters of grapes”

Answer 20

Complete Hydatidiform Mole, enucleated egg + 1 sperm

46,XX or XY

Question 21

“snowstorm” on Ultrasound

Answer 21

Complete Hydatidiform Mole, 46,XX or XY

Question 22

Tx of hydatidiform mole

Answer 22

D&C and methotrexate

Question 23

Benign warty growth on genital skin

Answer 23

Condyloma Acuminatum HPV6 or 11

Question 24

Necrotizing granulomatous inflammation of inguinal LN; eventually heals with fibrosis

Answer 24

Lymphogranuloma venereum (L1-3 C. trachomatis)

Question 25

Lower vestibule adjacent to vaginal canal is inflammed due to blockage

Answer 25

Bartholian Cyst

Question 26

Thinning of vaginal epithelium and fibrosis of dermis

Answer 26

Lichen Sclerosis

Question 27

Leukoplakia with parchment like vulvar skin; usually in post menopause

Answer 27

Lichen Sclerosis

Question 28

Lichen Sclerosis increases risk of what cancer

Answer 28

Squamous cell cancer

Question 29

Hyperplasia of vulvar; leukoplakia with THICK leathery vulvar skin

Answer 29

Lichen Simplex Chronicus

Question 30

E6

Answer 30

High risk HPV 16, 18, 31, 33 have this to increase p53 destruction

Question 31

E7

Answer 31

High risk HPV 16, 18, 31, 11 have this to increase Rb destruction