Breast Pathology Flashcards
Nipple diseases
Paget; Abscess
Lactiferous Sinus Diseases
Intraductal papilloma; abscess and mastitis
Major Duct Diseases
Fibrocystic change; DCIS; invasive ductal carcinoma
Terminal Duct Diseases
Tubular carcinoma
Lobule Diseases
Lobular Carcinoma
Breat Stroma Diseases
Fibroadenoma; phyllodes tumor
Small, mobile firm mass with sharp edges; Not a precursor to breast cancer
Fibroadenoma
Small tumor that grows in lactiferous ducts typically beneath areola; serous or bloody nipple discharge
Intraductal papilloma
“leaf like projections” most common in 50s
Phyllodes Tumor
Large bulky mass of CT and cysts
Phyllodes Tumor
Overexpression of c-erbB2 (HER-2)
Malignant breast tumor
LN used to indicated breast cancer metastasis
Axillary
Triple Negative breast cancer
ER (-); PR(-); and Her2/Neu (-)
most aggressive
BRCA1
Breast and Ovarian Carcinoma (medullary breast)
BRCA2
Breast carcinoma (in men too)
Most common male breast cancer
Invasive ductal carcinoma; assoc with BRCA2 and Klinefelter
Ductal Carcinoma In Situ (DCIS)
Fills ductal lumen; arises from ductal atypia; microcalcifications on mammography
Ductal caseous necrosis; dysmorphic calcification in center of ducts
Subtype of DCIS known as Comedocarcinoma
Ecxematous patches on nipple
from underlying DCIS; Pagets of breast (not vulva)
Large cells in epidermis with clear halo
Paget cells
malignant epithelium of vulva; erythematous, pruritic, ulcerated skin
Extramammary Paget
Firm, fibrous, “rock-hard” mass with sharp margins and small, glandular, duct-like cells
Invasive ductal breast cancer
Stellate infiltration
Invasive ductal breast cancer; worst and most invasive type
Orderly rows of cells “Indian File”
Invasive lobular breast cancer
Fleshy, cellular, lymphocytic (plasma) infiltrate
Medullary breast cancer; good prognosis
Dermal lymphatic invasion by breast carcinoma; Peau d’orange
Inflammatory breast cancer (neoplastic cells block lymphatic drainage
Most common cause of “breast lumps” from 25 to menopause; presents with premenstrual breast pain and multiple lesions; fluctuates in size
Proliferative Breast Disease
Types of Proliferative Breast disease
Fibrosis; cystic; sclerosing adenosis; epithelial hyperplasia
hyperplasia of breast stroma; breast pain with periods
Fibrosis type of proliferative breast disease
Fluid filled; blue dome; ductal dilation
Cystic type of prolfierative breast disease
Increased acini and intralobular fibrosis; associated with calcifications
Sclerosing adenosis; commonly confused with cancer
Increased number of epithelial cell layers in terminal duct lobule; increased risk of carcinoma with atypical cells
Epithelial Hyperplasia type os proliferative breast disease
Breast abscess during breast feeding
Acute mastitis
Most common bacteria that causes acute mastitis
S. aureus
Tx of acute mastitis
Dicloxacillin and continued breast feeding
Injury to breast tissue; abnormal calcification
Fat necrosis
Causes of Gynecomastia
Hyperestrogenism (cirrhosis, testcular tumor, puberty, old age); Klinefelter, Spironolactone, marijuana, digitalis, estrogen, cimetidine, alcohol, heroin, dopamine D2 antagonist, ketoconazole
