Path - viral infections

Question 1

Human cytomegalovirus - what kind of virus is it? Where does it reside?

Answer 1

double stranded DNA virus
Lies latent in monocytes and dendritic cells (phagocytes)

Question 2

What can be seen when looking at CMV cells down a microscope?

Answer 2

Owls eye inclusions

Question 3

Who does CMV impact?

Answer 3

Immunocompromised, esp post transplant
Neonates

Question 4

List some things that CMV can cause

Answer 4

Retinitis

Question 5

Management of CMV

Answer 5

Ganciclovir or valganciclovir IV
Foscarnet IV
Cidofovir IV

Question 6

HSV management

Answer 6

Aciclovir

Question 7

HSV 2 can cause

Answer 7

Genital ulceration
Herpes meningitidis
Sacral radiculomyelitis (self limiting urinary retention)

Question 8

What can HSV cause in immunocompromised people

Answer 8

Cutaneous dissemination
Oesophagitis - pain on swalliowing
Hepatitis
Viremia

Question 9

Congenital HSV consequences

Answer 9

Eye problems
Skin scarring
Neuro - miceocephaly, hydrancephaly, encephalomalacia

Question 10

Congenital HSV consequences

Answer 10

Eye problems
Skin scarring
Neuro - miceocephaly, hydrancephaly, encephalomalacia

Skin Eye Mouth (SEM)

Question 11

Mx of HSV in pregnancy

Answer 11

In pregnancy

Recurrent HSV - low risk of transmission to baby
HSV within 6 weeks of due date - go for c section
If after 28 weeks - continue aciclovir