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Boards First Aid and Kaplan > Path-Paraneoplastic Syndromes > Flashcards

Path-Paraneoplastic Syndromes Flashcards

1
Q

Describe acanthosis nigricans

A

Hyperpigmented velvety plaques in axilla and neck

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2
Q

What cancers is acanthosis nigricans most commonly associated with?
-Acanthosis nigricans is also associated with what other diseases?

A
  • Gastric adenocarcinomas and other visceral malignancies

- More commonly associated with obesity and insulin resistance

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3
Q

Describe the sign of Leser-Trelat

A

Sudden onset of multiple seborrheic keratoses

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4
Q

The Leser-Trelat sign is most commonly associated with what cancers?

A

Gastric adenocarcinomas and other visceral malignancies

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5
Q

What are the 2 possible mechanisms that lead to hypercalcemia?
-What cancer(s) is each mechanism associated with?

A
  • PTHrP -> Squamous cell carcinomas of the lung, head, and neck, renal, bladder, breast, and ovarian carcinomas
  • Excess vitamin D3 (active form/calcitriol) -> Lymphomas
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6
Q

What is Cushing syndrome?

A

Increased ACTH

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7
Q

Cushing syndrome is most commonly associated with what cancer?

A

Small cell lung cancer

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8
Q

Hyponatriemia (SIADH) is most commonly associated with what cancer?

A

Small cell lung cancer

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9
Q

What is polycythemia?

A

Increased EPO -> increased RBCs

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10
Q

Polycythemia is most commonly associated with what cancers?

A

Renal cell carcinoma, hepatocellular carcinoma, hemangioblastoma, pheochromocytoma, leiomyoma

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11
Q

What is pure red cell aplasia?

A

Anemia with low reticulocyte count

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12
Q

Pure red cell aplasia is most commonly associated with what cancer?

A

Thymoma

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13
Q

What is Good syndrome?

A

Hypogammaglobulinemia

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14
Q

Good syndrome is most commonly associated with what cancer?

A

Thymoma

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15
Q

What is Trousseau syndrome?

A

Migratory superficial thrombophlebitis

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16
Q

Trousseau syndrome is most commonly associated with what cancers?

A

Adenocarcinoma, especially pancreatic

17
Q

What is nonbacterial thrombotic (marantic) endocarditis?

A

Deposition of sterile platelet thrombi on heart valves

18
Q

Nonbacterial thrombotic (marantic) endocarditis is most commonly associated with what cancers?

A

Adenocarcinomas, especially pancreatic

19
Q

What are the symptoms of anti-NMDA receptor encephalitis?

A

Psychiatric disturbance, memory deficits, seizures, dyskinesias, autonomic instability, language dysfx

20
Q

Anti-NMDA receptor encephalitis is most commonly associated with what cancer?

A

Ovarian teratoma

21
Q

What are the symptoms of opsoclonus-myoclonus ataxia syndrome?

A

“Dancing eyes, dancing feet”

22
Q

Opsoclonus-myoclonus ataxia syndrome is most commonly associated with what cancer in ADULTS?

A

Small cell lung cancer

23
Q

Opsoclonus-myoclonus ataxia syndrome is most commonly associated with what cancer in CHILDREN?

A

Neuroblastoma

24
Q

What is the mechanism of paraneoplastic cerebellar degeneration?

A

Abs against Ags in Purkinje cells

25
Q

Paraneoplastic cerebellar degeneration is most commonly associated with what cancers
-What are the Abs associated with each?

A
  • Small cell lung cancer (anti-Hu)
  • Gynecologic and breast cancers (anti-Yo)
  • Hodgkin lymphoma (anti-Tr)
26
Q

What is the mechanism of paraneoplastic encephalomyelitis?

A

Abs against Hu Ags in neurons

27
Q

Paraneoplastic encephalomyelitis is most commonly associated with what cancer?

A

Small cell lung cancer

28
Q

What is the mechanism of Lambert-Eaton myasthenic syndrome?

A

Abs against PRE-synaptic (P/Q-type) Ca channels at NMJ

29
Q

Lambert-Eaton myasthenic syndrome is most commonly associated with what cancer?

A

Small cell lung cancer

30
Q

What is the mechanism of myasthenia gravis?

A

Abs against POST-synaptic Ach receptors at NMJ

31
Q

Myasthenia gravis is most commonly associated with what cancer?

A

Thymoma

Boards First Aid and Kaplan (19 decks)

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