Path-Oncogenes

Question 1

What has to happen in order for an oncogene to increase cancer risk?

Answer 1

Gain of function -> inc cancer risk

-Need damage to only ONE allele of an oncogene

Question 2

Name the gene product and neoplasm associated with ALK

Answer 2

Gene product-RTK

Associated neoplasm-Lung adenocarcinoma

Question 3

Name the gene product and neoplasms associated with BCR-ABL

Answer 3

Gene product-Tyrosine kinase

Associated neoplasm-CML, ALL

Question 4

Name the action and neoplasms associated with BCL-2

Answer 4

Gene product-Inhibits apoptosis

Associated neoplasm-Follicular and diffuse large B cell lymphoma

Question 5

Name the gene product and neoplasms associated with BRAF

Answer 5

Gene product-serine/threonine kinase

Associated neoplasm-melanoma, NHL, papillary thyroid carcinoma

Question 6

Name the gene product and neoplasm associated with c-KIT

Answer 6

Gene product-cytokine receptor

Associated neoplasm-GI stromal tumor (GIST)

Question 7

Name the gene product and neoplasm associated with c-MYC

Answer 7

Gene product-transcription factor

Associated neoplasm-Burkitt lymphoma

Question 8

Name the gene product and neoplasms associated with HER2/neu (c-erbB2)

Answer 8

Gene product-RTK

Associated neoplasm-breast and gastric carcinomas

Question 9

Name the gene product and neoplasm associated with JAK2

Answer 9

Gene product-Tyrosine kinase

Associated neoplasm-chronic myeloproliferative disorders

Question 10

Name the gene product and neoplasms associated with KRAS

Answer 10

Gene product-GTPase

Associated neoplasm-Colon, lung, and pancreatic cancers

Question 11

Name the gene product and neoplasm associated with MYCL1

-What is an easy way to remember the neoplasm?

Answer 11

Gene product-Transcription factor

Associated neoplasm-Lung tumor (MYCL1 has an L in it for Lung)

Question 12

Name the gene product and neoplasm associated with MYCN

-What is an easy way to remember the neoplasm?

Answer 12

Gene product-Transcription factor

Associated neoplasm-Neuroblastoma (MYCN has an N for Neuroblastoma)

Question 13

Name the gene product and syndromes and neoplasm associated with RET

Answer 13

Gene product-RTK

Associated syndromes and neoplasm-MEN 2A/2B and medullary thyroid cancer

Question 14

Name the gene product and neoplasm associated with

Answer 14

Gene product-

Associated neoplasm-