Kaplan Section 2 Pharm Flashcards
1
Q
Acetylcholinesterase inhibitors
A
- Edrophonium
- Physostigmine
- Neostigmine, pyridostigmine
- Donepezil, rivastigmine
- Organophosphates
2
Q
Edrophonium
A
- Short acting
- Used for the diagnosis of myasthenia gravis
3
Q
Physostigmine
A
- Tertiary amine (enters CNS)
- Used to treat glaucoma and as an antidote in atropine overdose
4
Q
Neostigmine and pyridostigmine
A
- Quaternary amines (no CNS entry)
- Used to treat ileus, urinary retention, myasthenia gravis, and reversal of non-depolarizing NM blockers (-curiums/-curoniums)
5
Q
Donepezil and rivastigmine
A
- Lipid soluble (CNS entry)
- Used to treat Alzheimer disease
6
Q
What is the equation for volume of distribution?
A
Dose/Concentration at time 0
7
Q
What is the equation for half life?
A
.7 x (Volume of distribution/clearance)
8
Q
What is the equation for infusion rate?
A
Clearance x steady state concentration
9
Q
What is the equation for loading dose?
A
(Volume of distribution x plasma concentration)/(bioavailability)
10
Q
What is the equation for maintenance dose?
A
(Clearance x steady state concentration x dosing interval)/(bioavailability)
