Autonomic Drug Classifications Flashcards
Cholinomimetics/direct cholinergic receptor activators
- Bethanechol (M)
- Methacholine (M and N)
- Nicotine (N)
- Pilocarpine (M)
- Cevimeline (M)
Reversible AChE inhibitors (indirect cholinomimetics)
- Edrophonium
- Physostigmine
- Neostigmine
- Pyridostigmine
- Donepezil
- Rivastigmine
Which AChE inhibitors are quaternary and what does this mean?
Quaternary AChE inhibitors are unable to get into the CNS
- Pyridostigmine
- Neostigmine
- Edrophonium
Irreversible AChE inhibitors?
- Malathion
- Parathion
Muscarinic antagonists
- Atropine
- Scopolamine
- Benztropine
- Ipratropium/tiotropium
- Oxybutynin
- Trihexyphenidyl
Ganglionic blockers
- Hexamethonium
- Mecamylamine
Alpha1 agonist
-Phenylephrine
Alpha2 agonists
- Clonidine
- Methyldopa
Beta agonists
- Isoproterenol (B1 = B2)
- Dobutamine (B1 > B2)
Beta2 agonists
- Albuterol
- Terbutaline
- Salmeterol
What are the receptors activated by dopamine?
D1, Beta1, Alpha1
What are the receptors activated by epinephrine?
Alpha1, alpha2, beta1, beta2
What are the receptors activated by norepinephrine?
Alpha1, alpha2, beta1
What are the indirect acting adrenergic receptor activators/sympathomimetics?
- Amphetamine
- Cocaine
- Ephedrine
- Tyramine
Alpha1 antagonists
- Doxazosin
- Prazosin
- Terazosin
Alpha2 antagonist
Mirtazapine
Mixed alpha antagonists
- Phentolamine
- Phenoxybenzamine
Beta1 antagonists
B1 = cardioselective
- Atenolol
- Betaxolol
- Esmolol
- Acebutolol
- Metoprolol
Non-selective beta blockers?
- Pindolol
- Propanolol
- Timolol
Alpha1/beta antagonists
- Labetalol
- Carvedilol
Name the main areas affected by alpha1 receptors and their effects on these areas
- Eye-contraction of the radial/dilator muscle -> mydriasis
- Arterioles (skin/viscera)-Contraction -> Inc TPR, diastolic pressure, and afterload
- Veins-Contraction -> Inc venous return and preload
- Bladder/urinary system-Contraction -> Urinary retention
Name the main area affected by alpha2 receptors and their effects on this area
Prejunctional nerve terminals -> Decrease transmitter release and NE synthesis
Name the main areas affected by beta1 receptors and their effects on these areas
Heart
-SA node-positive chronotropy (HR)
-AV node-positive dromotropy (Conduction velocity)
-Atrial and ventricular muscle-positive inotropy (contraction force)
-His-Purkinje-Inc automaticity and positive dromotropy
Kidney (JGA cells) -> Inc renin release
Name the main areas affected by beta2 receptors and their effects on these areas
- Blood vessels (all)-vasodilation -> dec TPR, diastolic pressure and afterload
- Uterus -> relaxation
- Bronchioles -> dilation
