Antiprotozoal Agents Flashcards
What is the DOC for amebiasis?
Metronidazole (diloxanide for noninvasive intestinal amebiasis)
What is the DOC for toxoplasmosis?
Pyrimethamine + sulfadiazidine
What is the DOC for leishmaniasis?
Stibogluconate
What is the DOC for giardiasis?
Metronidazole (backpacker’s diarrhea from contaminated water/food)
What is the DOC for trypanosomiasis?
- Nifurtimox (Chagas disease)
- Arsenicals (African)
What is the DOC for trichomoniasis?
Metronidazole (treats both partners)
Chloroquine alone is the treatment for what types of malaria?
Falciparum and malariae
Chloroquine + primaquine is the treatment for what types of malaria?
Vivax and ovale
What is used for prophylaxis is chloroquine-resistant regions?
Mefloquine
What is used for treatment chloroquine-resistant regions?
Quinine +/- either doxycycline or clindamycin or pyrimethamine
What are the possible side effects of primaquine and quinine?
-Hemolytic anemia in G6PD deficiency
What antimalarial drug causes cinchonism?
Quinine
What drugs are used for most intestinal nematodes (worms)?
- Albendazole
- Pyrantel pamoate
What is the MOA of albendazole?
Decreased glucose uptake and microtubular structure
What is the MOA of pyrantel pamoate?
Nm agonist (can cause spastic paralysis)
What drug is used for most cestodes (tapeworms) and trematodes (flukes)?
Praziquantel
What is the MOA of praziquantel?
Increased Ca influx and vacuolization
