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FA > Path > Flashcards

Path Flashcards

1
Q

BAX

A

pro-apoptotic

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2
Q

Bcl-2

A

anti-apoptotic

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3
Q

neutrophil rolling

A

E/P-selectin –> sialyl-lewisX

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4
Q

neutrophil tight binding

A

ICAM1 –> LFA-1 (integrin)

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5
Q

neutrophil diapedesis

A

PECAM1

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6
Q

neutrophil migration

A

CILK - C5a, IL-8, LTB4, Kallikrein

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7
Q

disease conditions associated with down syndrome

A

ALL, AML

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8
Q

disease conditions associated with xeroderma pigmentosum, albinism

A

melanoma, basal cell carcinoma, squamous cell carcinoma of skin**

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9
Q

disease conditions associated with tuberous sclerosis (facial angiofibroma, seizures, mental retardation)

A

giant cell astrocytoma, renal angiomyolipoma and cardiac rhabdomyoma

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10
Q

disease conditions associated with actinic keratosis

A

squamous cell carcinoma ofskin

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11
Q

disease conditions associated with barrett’s esophagus (chronic GI reflux)

A

esophageal adenocarcinoma

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12
Q

disease conditions associated with plummer-vinson syndrome (low iron)

A

squamous cell caricnoma of esophagus

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13
Q

disease conditions associated with cirrhosis (alcoholic, hep B or B)

A

hepatocellular carcinoma

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14
Q

disease conditions associated with ulcerative colitis

A

colonic adenocarcinoma

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15
Q

disease conditions associated with pagets disease of bone

A

secondary osteosarcoma and fibrosarcoma

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16
Q

disease conditions associated with immunodeficiency states

A

malignant lymphoma

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17
Q

disease conditions associated with AIDS

A

aggressive malignant lymphoma (NH) and kaposis sarcoma

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18
Q

disease conditions associated with autoimmune diseases (hashimoto, MG)

A

lymphoma

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19
Q

disease conditions associated with acanthosis nigricans (hyperpigmentation and epidermal thickenign)

A

visceral malignancy (stomach, lung, uterus)

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20
Q

disease conditions associated with dysplastic nevus

A

malignant melanoma

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21
Q

disease conditions associated with radiation exposure

A

leukema, sarcoma, papillary thyroid cancer, breast cancer

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22
Q

abl

A

oncogene* CML –> tyrosine kinase

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23
Q

c-myc

A

oncogene* burkitts lymphoma –> transcription factor

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24
Q

bcl-2

A

oncogene* follicular and undifferentiation lymphomas (inhibits apoptosis) –> anti-apoptotic molecule

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25
Q

HER2/neu (c-erbB2)

A

oncogene* breast ovarian and gastric carcinoma –> tyrosine kinase

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26
Q

ras

A

oncogene* colon carcinoma –> GTPase

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27
Q

L-myc

A

oncogene* lung tumor –> transcription factor

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28
Q

N-myc

A

oncogene* neuroblastoma –> transcription factor

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29
Q

ret

A

oncogene* MEN 2a and 2b –> tyrosine kinase

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30
Q

c-kit

A

oncogene* GI stromal tumor –> cytokine receptor

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31
Q

Rb

A

tumor suppressor gene* retinoblastoma, osteosarcoma –> inhibits E2F; blocks G –> S phase

32
Q

p53

A

tumor suppressor gene* most human cancers, li-fraumenni syndrome –> transcription factor for p21, blocks G1 –> S

33
Q

BRCA1 and BRCA2

A

tumor suppressor gene* breast and ovarian cancer –> DNA repair protein

34
Q

p16

A

tumor suppressor gene* melanoma

35
Q

BRAF

A

tumor suppressor gene* melanoma –> B-raf

36
Q

APC

A

tumor suppressor gene* colorectal cancer (FAP)

37
Q

WTT

A

tumor suppressor gene* Wilms tumor (nephroblastoma)

38
Q

NF1

A

tumor suppressor gene* neurofibromatosis type 1 –> RAS GTPase activating protein (RAS-GAP)

39
Q

NF2

A

tumor suppressor gene* neurofibromatosis type 2 –> merlin (schwannomin) protein

40
Q

DPC4

A

tumor suppressor gene* pancreatic cancer –> DPC = DELETED IN PANC CANCER

41
Q

DCC

A

tumor suppressor gene* colon cancer –> DCC = DELETED IN COLON CANCER

42
Q

PSA

A

prostate specific antigen

43
Q

prostatic acid phosphatase

A

prostate carcinoma

44
Q

CEA

A

carcinoembryonic antigen

45
Q

alpha fetoprotein

A

hepatocellular carincoma

nonseminmotous germ cell tumors (testis/ovarY)

46
Q

beta-HCG

A

hydatidiform moles and choriocarcinomas (gestational trophoblastic disease)

47
Q

CA-125

A

ovarian cancer

48
Q

S-100

A

melanoma, neural tumors, schwannoma

49
Q

alkaline phosphatase

A

metastases to bone, liver, pagets disease of bone

50
Q

bombesin

A

neuroblastoma, lung and gastric cancer

51
Q

TRAP

A

hairy cell leukemia - B cell neoplasm

52
Q

CA-19-9

A

pancreatic adenocarcinoma

53
Q

calcitonin

A

medullary thyroid carcinoma

54
Q

HTLV-1

A

adult T-cell leukema/lymphoma

55
Q

HBV/HCV

A

hepatocellular carcinoma

56
Q

EBV

A

burkitts lymphoma, hodgkins lmohoma, nasopharyngeal carcinoma, CNS lymphoma (IC patients)

57
Q

HPV

A

cervical carcinoma (16,18), penile/anal carcinoma, upper resp SCC

58
Q

HHV-8 (kaposi’s sarcoma-associated herpesvirus)

A

kaposis sarcoma, body cavity fluid B-cell lymphoma

59
Q

H. pylori

A

gastric adenocarcinoma and lymphoma

60
Q

schistosoma haematobium

A

bladder cancer (squamous cell)

61
Q

liver fluke (clonorchis sinensis)

A

cholangiocarcinoma

62
Q

aflatoxin (aspergillus)

A

liver –> hepatocellular carcinoma

63
Q

vinyl chloride

A

liver –> angiosarcoma

64
Q

carbon tetrachloride

A

liver –> centrilobular necrosis, fatty change

65
Q

nitrosamines (smoked foods)

A

stomach –> gastric cancer

66
Q

cig smoke

A 
larynx --> squamous cell carcinoma
lung --> squamous cell and small cell carcinoma
kidnye --> renal cell carcinoma
bladder --> transitional cell carcinoma
pancreas --> panc adenocarcinoma
67
Q

asbestos

A

lung –> bronchogenic carcinoma > mestholeioma

68
Q

arsenic

A

skin –> squamous cell carcinoma

liver –> angiosarcoma

69
Q

naphthalene (aniline) dyes

A

bladder –> transitional cell carcinoma

70
Q

alkylating agents

A

blood –> leukemia

71
Q

ACTH

A

cusshings syndrome –> small cell lung carcinoma

72
Q

ADh

A

SIADH –> small cell lung carcinoma and intracranial neoplasma

73
Q

PTHrP

A

hypercalcemia –> squamous cell lung carcinoma, renal cell carcinoma, breast cnacer

74
Q

1,25-OH2 D3 = calcitrol

A

hypercalcemia –> hodgkins lymphoma, some NHL

75
Q

erythropoietin

A

polycythemia –> renal cell carcinoma, hemagioblastoma, hepatocellular carcinoma, pheochromocytoma

76
Q

antibodies vs presynaptic calcium channels at NMJ

A

lambert eaton syndrome (muscle weakness) –> small cell lung carcinoma

77
Q

psammoma bodies

A

laminted concentrated calcific spherules seen in papillary andenocarcinoma or thyroid, serous papillary cystadenocarcinoma of ovary, meningioma, malignant mesothelioma

FA (13 decks)

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