Passive Transport Flashcards
What is Passive transport?
Diffusion/Osmosis, doesn’t require energy
Explain the 2 types of simple diffusion?
Lipid soluble: thru lipid bilayer
Water soluble: thru pore or gated ion channel
What substances pass in Lipid Soluble simple diffusion?
CO2, O2, ethanol, lipid-soluble substances
What substances pass in Water Soluble simple diffusion?
H2O + ions
What does Facilitated Diffusion require? Explain the 4 glucose transporters
Requires a transporter
Glut1: 1-way
Glut2: both ways
Glut4: 1-way
SGlut1: Na symport (2 molecules simultaneous in same direction)
All of the facilitated diffusion glucose transporters are Insulin Independent EXCEPT
Glut4 (1-way)
What is the location of the glucose transporter Glut1?
Brain + RBCs
What is the location of the glucose transporter Glut2?
Liver
What is the location of the glucose transporter Glut4?
Muscle + Adipose
What is the location of the glucose transporter SGlut1?
GI tract + Kidney
Simple diffusion takes place in __________. What simple diffusion takes place in NERVE cells?
All cells
H2O soluble
Explain Osmosis, what does it depend on?
Movement of H2O from [low solute] —> [high solute]
Depends on # (NOT size) of the particles
In terms of Osmosis, how many molecules are in glucose? Albumin? NaCl? CaCl2? How is this calculated?
Glucose = 1 particle
Albumin = 1 particle
NaCl = 2 particles
CaCl2 = 3 particles
Using osmotic pressure: #particles x [Molar]
What are perfect osmometers?
What happens to RBC in Isotonic solution? Hypotonic solution? Hypertonic solution?
RBCs
Isotonic solution: stay same size
Hypotonic solution: swells + bursts (lyses)
Hypertonic solution: shrinks (crenate)
Facilitated diffusion has similar kinetics to what? Why is this? Draw a chart of rate of uptake vs. concentration for simple + facilitated diffusion
Active transport; b/c requires a transporter
