Paracrine Mediators Flashcards
Name the paracrine mediator amines
Histamine, Nitric Oxide (NO)
Histamine is made by _____ which have _____ molecules on their surface, and are located where?
Mast cells
IgE
In CT of bronchi + intestines
Name the paracrine mediator polypeptide growth factors
Mitogens, Trophic factors, Chemoattractants
Mitogen is a growth factor that…
Stimulates cell proliferation (mitosis)
Trophic factors are growth factors that play a role in…
Growth + survival
Chemoattractants are growth factors which are a…
Gradient for mobile (WBC) cells (inflammation)
(Call cells over)
How is histamine released from the mast cells?
Allergen binds causing crosslinks btwn IgE molecules; Ca+ enters cell —> histamine released
H1 histamine receptor causes venules to _____, which…
Vasodilate
^tissue swelling + ^WBC infiltration into tissue
H1 histamine receptor causes the release of _____, which…
Hypothalamic Releasing factors
^release of Ant. Pituitary Hormone
H2 histamine receptor causes the release of _____ from _____.
Stomach acid
Parietal cells in stomach
Nitric Oxide (NO) works as a _____ to _____.
Localized negative feedback
Vasoconstriction
What are the two Paracrine Mediators?
Polypeptide Growth factors; Amines
How do arterioles constrict?
Epinephrine or norepinephrine
Arteriole constriction causes the release of _____ by endothelial cells
Acetylcholine
The release of Acetylcholine __________ to endothelial cells
Increases Ca+ influx
