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Cell Physiology > Cell Adhesion Molecules > Flashcards

Cell Adhesion Molecules Flashcards

1
Q

What is the structure of Tight Junctions

A

Barrier at apical border
Cell-cell

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2
Q

What is the function of Tight Junctions

A

BBB
Integrity of epithelial layer

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3
Q

What is the structure of Adherens Junctions

A

Apical region of cell below tight junctions
Allows neural tube development
Cell-cell

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4
Q

What is the function of Adherens Junctions

A

Cytoskeleton - contractile actin network
Linker glycoprotein - cadherins

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5
Q

What happens to Adherens Junctions in the absence of Ca+?

A

Junction opens, is cause of dysfunctions such as “leaky gut”

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6
Q

What is the structure of Desmosomes?

A

Spot junction: cell-cell

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7
Q

What is the function of Desmosomes?

A

Maintains epithelial integrity
Cytoskeleton intermediate filaments

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8
Q

What is the structure of Gap Jcts?

A

Communicating junctions (AKA)

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9
Q

What is the function of Gap Jcts?

A

Transfer chemical/electrical signals btwn neighboring cells

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10
Q

What is the structure of Hemidesmosomes?

A

Connects cells to basal lamina
Cell-matrix

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11
Q

What is the function of Hemidesmosomes?

A

Cytoskeleton intermediate filaments

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12
Q

What is the structure of the Extracellular Matrix?

A

Main components of CT:
Glycosaminoglycans, Fibrous Proteins, Adhesive Proteins

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13
Q

What is the structure of Glycosaminoglycans?

A

Highly negative charged sulfates
Especially important in joints w/ protein- Proteoglycans
Bottle-brush appearance

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14
Q

What is the function of Glycosaminoglycans

A

Attract Na+ (draw water in) = swelling/turgor

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15
Q

Define Turgor

A

Resists tissue compression

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16
Q

Name the 2 Fibrous proteins made by fibroblasts

A

Collagen, Elastin

17
Q

What is the function of Collagen? What is the structure?

A

Resist shearing
Organized in fibrils, can be bundled into fibers

18
Q

What is the function of Elastin? What is its structure

A

In tissues able to stretch + recoil BVs, skin, lungs
In extracellular-space cross-linked

19
Q

What is the structure of Adhesive Glycoproteins

A

Contain domains that:
- Binds to cell surfaces
- interacts w/ collagen
- binds proteoglycans

20
Q

What is the function of Adhesive Glycoproteins

A

Extracellular glue

Cell Physiology (17 decks)

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