part 7 Flashcards
This medication is rarely used because of adverse effects?
Thiazolidinediones
This medication is referred to as an insulin sensitizer.
Thiazolidinediones
- most effective in those with insulin resistance
- improves insulin sensitivity, transport, and utilization at target tissues
Thiazolidinediones
What are some examples of Thiazolidinediones?
- Pioglitazone (Actos)
- Rosiglitazone (Avandia)
Because Thiazolidinediones do not increase insulin production when used alone what do they not cause?
hypoglycemia
What does Dipeptidyl Peptidase-4 (DDP-4) Inhibitor/Glipitins do?
- blocks inactivation of incretin hormones (incretins secrete insulin)
- increase insulin release
- decrease glucagon secretion (does not makes more glucose)
- decreases hepatic glucose production
What are examples of Dipeptidyl Peptidase-4 (DDP-4) Inhibitor/Glipitins?
- Sitagliptin (Januvia)
- Saxagliptin (Onglyza)
- Linagliptin (Tradjenta)
What do Glucagonlike Peptide-1 Receptor Agonists do?
simulate glucagonlike peptide-1 (GLP-1)
- increases insulin synthesis and release
- inhibits glucagon secretion
- slows gastric emptying
- increases satiety
GLP-1
Why does a pt taking a GLP-1 need to be mindful about when other medications are taken?
this medication causes delayed gastric emptying and may effect the absorption of oral medications
What is the only available Amylin Analog?
Pramlintide (Symlin)
What is Pramlintide (Symlin) the Amylin Analog used concurrently with?
insulin
- slows gastric emptying
- reduces postparandial glucagon secretion
- increases satiety
Pramlintide (Symlin) the Amylin Analog
When and where is Pramlintide (Symlin) the Amylin Analog given and what do we need to watch for?
- subcutaneously in thigh or abdomen
- give before meals
- watch for hypoglycemia (about 3 hours after injection, have insulin on hand)
Who can use Pramlintide (Symlin) the Amylin Analog?
pts with T1 or T2DM
