part 5

Question 1

What type 2 diabetes drugs act on adipose tissue and muscles? And what do they do?

Answer 1

• biguanides and thiazolidinediones
• increase uptake and use of glucose
• decrease insulin resistance (or increase sensitivity)

Question 2

What type 2 diabetes drugs act on the pancreas? And what do they do?

Answer 2

• sulfonylureas
• meglitinides
• DPP-4 inhibitors
• GLP-1 receptor agonists
• they increase insulin production

Question 3

What type 2 diabetes drugs act on the stomach and small intestine? And what do they do?

Answer 3

• alpha-glucosidase inhibitors: delay absorption of starches
• DPP-4 inhibitors: increase activity of incretins
• GLP-1 receptor agonists and amylin: decrease gastric emptying

Question 4

What type 2 diabetes drugs act on the liver? And what do they do?

Answer 4

• biguanides (metformin)
• thiazolidinediones
• DPP-4 inhibitors
• decrease hepatic glucose production

Question 5

What type 2 diabetes drugs act on the kidney? And what do they do?

Answer 5

• SGLT inhibitors

- decrease glucose reabsorption (decrease re-uptake)

Question 6

Biguanides

Answer 6

-metformin (glucophage)