Parkinsons

Question 1

Where in the brain is affected with Parkinsons

Answer 1

basal ganglia

–> decrease in dopamine in basal ganglia

Question 2

symptoms of Parkinsons - 4 (ways they act)

Answer 2

temor
rigidty
akensia
postural instability

Question 3

Aeitology

Answer 3

uknown
idiopathic familial
drug
trauma
metabolic (wilsons)
psychogenic
vascular

Question 4

is Parkinsons neurodegenerative?

Answer 4

yes

Question 5

Parkinsons pathology - 4

Answer 5

subcortical grey matter affected
decrease NT dopamine in basal ganglia
Ach imbalance - gives motor signs
cellular occlusions aggregate - lewy bodies

Question 6

what does subcortical grey matter in brain do?

Answer 6

movement and posture

Question 7

imbalance in what gives motor signs?

Answer 7

Ach

Question 8

what is it called when cellular occlusions to aggregate

Answer 8

lewy bodies

Question 9

what is Parkinsons plus - 2 features

Answer 9

parkinsons features with added features
system atrophy
shy dagger - automatic body function alteration

Question 10

Parkinsons presentation - 4

Answer 10

pea rolling remor
flexed joints
incontinence
postural hypertension

Question 11

2 steps to diagnose Parkinsons

Answer 11

1. use PDS brain bank criteria

2. rule out other conditions

Question 12

Imaging for Parkinsons?

Answer 12

no

Question 13

bradykinesia can include 3 things…

Answer 13

1. rigidity
2. resting tremor
3. postural instability

Question 14

differential diagnosis for Parkinsons

Answer 14

tremor
drug induced Parkinsonism
WIlsons
Lewy body demention

Question 15

treatment for Parkinsons

Answer 15

l dopa
moa- b inhibitors
com-t inhibitors
dopamine agonits
amatidine
anticholinergics
anti depressants
anti psychotics

Question 16

what is the on and off phenomenon

Answer 16

1. increased tolerate to drug - increase dose by increasing frequency
2. add COMT - entecapone

Question 17

2 non pharmacological treatments

Answer 17

1. deep brain stimulation

2. non pharmacological