Myasthensia Gravis Flashcards
what kind of disease?
autoimmune
what kind of autoimmune disease?
t and b cell
what neurotransmitter is affected?
Ach
what defect in the synaptic transmission?
decrease amount of working receptor sites of Ach
how does MG present - 2 main
muscle fatigue
- extraoccular
- bulbar (swallowing and chewing)
- face
- neck
- limb
- girdle
- trunk
diplopia
what is muscle fatigue in MG worsened by? 4
pregnancy, decrease in K, infection, drugs
what 2 characteristics is MG associated with in less than 50s?
females
other autoimmune conditions
what is MG associated with in more than 50s?4
males
thymic atrophy
tumour
SLE, RA
what investigations should you do for MG? 2
antibodies - anti-AchR, MUSK
CT of thymus
treatment for MG
- symptoms
- immunosuppresion
- osteoporosis
symptoms: anticholinesterase
immunosuppression: pred for relapse
osteoporsis - prophylaxis
steriod
thymoectomy
when should you do a thymoectomy?
if onset before 50 y/o and anticholinerse not controlling it
what happens in MG crisis
weakness of resp muscles in relapse - can be life threatening
