parkinson's: COMT inhib, MAO inhib

Question 0

which 2 drugs prolong Levodopa T1/2, reduce “off” times, primarily works peripherally

Answer 0

entacapone

tolcapone

Question 1

name 2 COMT inhibitors, how do they work?

Answer 1

1. entacapone
2. tolcapone

prevents DA breakdown

Question 2

what are ADRs of short-acting entacapone? (D’s)

Answer 2

inc dyskinesias, diarrhea, urine discoloration, DA-side effects

Question 3

which drug causes fatal hepatotoxicity and all the ADRs of entacapone? (you use this only when entacapone fails)

Answer 3

tolcapone

Question 4

what are the 2 MAO-B inhibitors that prevents DA breakdown?

Answer 4

1. Selegiline

2. Rasagiline

Question 5

used as monotherapy for mild PD, may delay onset of levodopa therapy

Answer 5

1. selegiline

2. rasagiline

Question 6

can be used as an adjunct with levodopa to reduce off time

Answer 6

rasagiline

Question 7

MAO-B inhibitors that cause hypoTN, GI distress, dyskinesia, psychosis, N/V

Answer 7

selegiline and rasagiline

Question 8

can be give as an ANTIDOTE to environmental TOXINS

Answer 8

selegiline

Question 9

CI to use selegiline and rasagiline?

Answer 9

decongestants, dextromethorphan, St. John’s wort, analgesics, methadone, tramadol, propoxyphene, caution with SSRIs, MAO-A inhibitors