neuroleptics - 1st gen antipsychotics Flashcards
what are the 5 phenothiazines?
- chlorpromazine
- fluphenazine
- trifluoperazine
- perphenazine
- thioridazine
name the 8 first generation antipsychotics
- chlorpromazine
- fluphenazine
- trifluoperazine
- perphenazine
- thioridazine
- thiothixene
- loxapine
- haloperidol
what drug is a thioxanthine?
thiothixene
what drug is dibenzoxazepine?
loxapine
what drug is butyrophenone?
haloperidol
what dz and sx are the first generation antipsychotics used to tx?
schizophrenia (hallucinations, delusions), and movemt dis in Huntington’s
what’s the major ADR of the first generation antipsychotics? (what are the first gen’s again?)
(TTT - 3operas; when u get a flu, you need a halo (angel), lox (omegas), and perfectionist (at taking care of u), and chlorine to kill all the germs)
NMS;
chlorpromazine, fluphenazine, trifluoperazine, perphenazine, thioridazine, thiothixene, loxapine, haloperiodol
T/F: the first gen antipsychotics have effect on negative sx of schizophrenia
F; little effect on negative sx.
what are some of the ADRs of 1st gen antipsychotics?
EPS, TD, sedation, postural hypoTN, weight gain, anticholinergic effects, sexual dysfnc, hyperprolactinemia
what is catalepsy?
trance, mm rigidity, lack of voluntary movement.
DA depleting, VMAT2 inhibitor
Tetrabenazine
mm relaxant
dantrolene
for movmt disorders in Huntington’s and for tardive dyskinesia
tetrabenazine
to tx malignant hyperthermia (assoc with NMS)
dantrolene
ADR of tetrabenazine
NMS
