neuroleptics - 2nd gen antipsychotics Flashcards
which of the 2nd gen antipsychotics are D2 receptor and 5HT2 receptor antagonists?
clozapine olanzapine quetiapine risperidone ziprazidone paliperidone
what are the 7, 2nd generation antipsychotics?
- clozapine
- olanzapine
- Quetiapine
- risperidone
- ziprazidone
- paliperidone
- aripiprazole
what drug is an active metabolite of risperidone after P450 metabolism?
paliperidone
what drug is partial D2, D3 receptor agonist, partial 5HT1a agonist, and 5HT2a antagonist
aripriprazole
which of the 2nd gen antipsychotics are tricylics?
clozapine
olanzapine
quetiapine
which of the 2nd gen antipsychotics are non-tricyclics?
- risperidone
- ziprazidone
- paliperidone
- aripiprazole
which 2nd gen antipsychotic have these ADRs: agranulocytosis, weight gain, T2DM, seizure risk, hyperlipidemia? also akathesia (rare, at high doses), GI hypomotility, myocarditis
clozapine
for tx tx-resistant psychoses (incl schizophrenia); dec suicide risk, can be used in pregnancy
clozapine
what drug does not produce catalepsy, EPS, or TD
clozapine
which 2nd gen antipsychotics tx schizophrenia (pos sxs, and modest effect on neg sx), and severe bipolar? and produces ADRs like metabolic complications (weight gain, hyperglycemia, T2DM, hyperlipidemia), somnolence, dizziness, inc liver transaminases, postural hypoTN, constipation, EPS, hyperprolactinemia, akathesia may occur.
olanzapine
which 2nd gen antipsychotics are useful for tx positive sx of schizo, with modest effects on negative?
all second gen antipsychotics
which ones also tx bipolar?
olanzapine, risperidone, aripiprazole
most of the 2nd gen antipsychotics have ADRs like metabolic complications (weight gain, hyperglycemia, T2DM, hyperlipidemia), postural hypoTN, constipation, somnolence, and dizziness. Which one has fever metabolic complications compared to tricyclics, but highest in EPS in 2GA?
risperidone
which one has few metabolic complications compared to tricyclics, EPS in 5%? but has cardiac arrhythmias (QTc prolongation)
ziprazidone
which ones have fewer metabolic complications compared to tricyclics, but have pssobiel QTc prolongation, possible EPS?
ziprazidone, paliperidone (also risk of hyperprolactinemia in palip)
