general anesthetics 2

Question 0

3 amino steroid non-dep NMB

Answer 0

1. pancuronium
2. vecuronium
3. rocuronium

Question 1

depolarizing NMB

Answer 1

succinylcholine

Question 2

selective relaxant binding agent

Answer 2

sugammadex

Question 3

2 isoquinoline nondep NMB

Answer 3

atracurium and cis-atracurium

Question 4

admin NBM and you see fasiculations and then paralysis;

-sk mm relaxant (for intubation pts)

Answer 4

succinylcholine

Question 5

the only NBM with rapid onset and ultra-short duration of action

Answer 5

succinylcholine

Question 6

SE: maligant hyperthermia
cardiac dysrhythmias, hyperkalemia
inc IOP, ICP, IGP
myalgias, masseter spasm

Answer 6

succinylcholine

Question 7

hydrolyzed by pseudocholinesterase in plasma and its blockade cannot be reversed

Answer 7

succinylcholine

Question 8

3 competitive ach blockade with depolarization

Answer 8

1. pancuronium
2. vecuronium
3. rocuronium

(all amino steriod non dep NMBs)

Question 9

all 3 amino steroid non-dep NMB are sk mm relaxants; which one should be avoided in pts with renal insuff?

Answer 9

pancuronium

Question 10

only LONG-ACTING nondep agent that’s supplied as liquid; mostly excreted unchanged in liver (low met by liver)

Answer 10

pancuronium

Question 11

the only amino steroid non-dep NMB thats vagolytic

Answer 11

pancuronium

Question 12

2 amino-steroid non dep NMB that has no CV effects

Answer 12

vecuronium and rocuronium

Question 13

which amino steroid nondep nmb can succinylcholine be subbed in rapid sequence intubation?

Answer 13

rocuronium

Question 14

both intermediate acting, liver met and liver and renal excretion

Answer 14

vecuronium and rocuronium

Question 15

___complexes with ___ to make it inactive; but this is special in that it doesnt need to be admin with antimuscarinic bc it has no effect on AchE

Answer 15

sugammadex, rocuronium

sugammadex used for immediate reversal of rocuronium

Question 16

SE of sugammadex?

Answer 16

dry mouth, dec BP, N/V

Question 17

1. sk mm relaxant that is used in pts with renal or liver dysfnc (2) (are they long/short/intermediate acting?);
2. which one causes histamine release (esp if given as rapid IV bolus)–> hypoTN and tachy?
3. why are they for pts with renal/liver dysnf?

Answer 17

1. atracurium, cis-atracurium (both intermediate acting)
2. atracurium
3. spontaneous, non-enzymatic degration (Hofman elimination

Question 18

NMB that can be reversed with achEI (5)

Answer 18

pancuronium
vecuronium
rocuronium
atracurium
cis-atracurium

Question 19

3 achE-I

Answer 19

1. edrophonium
2. neostigmine
3. pyridostigmine

Question 20

which one is most commonly used for reversal of NMB?

Answer 20

neostigmine

Question 21

1. longest duration of action of the AchE-Is?
2. fast onset, short acting?
3. more complete antagonism than edrophonium?

Answer 21

1. pyridostigmine
2. edrophonium
3. neostigmine

Question 22

anti-muscarinic that reverses NMB’s muscaranic effects?

onset = onset of neostigmine

Answer 22

glycopyrrolate (can also use atropine)