narcotics

Question 0

which opioids bind mu-opioid receptors but it has low receptor affinity (thus a weak analgesic) BUT also have some NE/5HT uptake inhibition (which results in what bc of this particular action?)

Answer 0

codeine

Question 1

all opioids bind to which receptor?

Answer 1

Mu-opioid receptor

Question 2

which opioid is a weak analgesic in itself, but it demethylates to morphine and is found in many cough meds?

Answer 2

codeine

Question 3

SE of all opioids?

Answer 3

major: miosis, constipation, respiratory depression

Dry mouth, N/V, sedation, sweating, dreams, dysphoria, delirium, myoclonus, seizures, pruritis, urticaria, urinary incontinence

Question 4

which opioid has M3 and M6 metabolites? Which metabolite is more potent/active?

Answer 4

morphine; M6

Question 5

which opioid gives you mood alteration in addition to providing analgesia for severe pain? what are some of the other effects of this drug?

Answer 5

morphine; severe analgesia, mood alteration, antitussive, sedation

Question 6

which drug may have SE in caucasians w/o drug effect? (cannot be converted to active)

Answer 6

codeine

Question 7

synthetic codeine analog

Answer 7

tramadol

Question 8

for:
1. severe analgesia
2. moderate analgesia
3. moderate to severe analgesia

Answer 8

1. morphine
2. codeine, tramadol
3. oxycodone, fentanyl

Question 9

list all the opioids (10)

Answer 9

1. morphine
2. codeine
3. tramadol
4. fentanyl
5. methadone
6. oxycodone
7. meperidine
8. propoxyphene
9. loperamide
10. diphenoxylate

Question 10

2 opioids for tx diarrhea

Answer 10

loperamide and diphenoxylate

Question 11

slows peristalsis via opioid receptors in intestine, possible decrease GI secretion

Answer 11

loperamide and diphenoxylate

Question 12

meperidine congener (2)

Answer 12

loperamide and diphenoxylate

Question 13

which opioid can be administered IV or via transdermal (intraspinal possible) and has a long T1/2 (cannot change dose more than 1/week)

Answer 13

fentanyl

Question 14

which opioid is highly lipid-soluble

Answer 14

fentanyl

Question 15

which opioid is for tx chronic, severe pain as well as heroin and opioid addicts?

Answer 15

methadone

Question 16

mostly bound to plasma protein and accumulates in tissues (thus, extended duration of action, thus do not change dose more than 1/wk (long T1/2))

Answer 16

methadone

Question 17

for moderate to severe pain, oxycontin is the extended release form

Answer 17

oxycodone

Question 18

not supposed to use this opioid because it makes normeperidine metabolite (causes AMS, seizures, in addition to miosis, resp depression, constipation)

Answer 18

meperidine

Question 19

dont use this opioid bc it makes norpropoxyphene (CNS toxicity), which has a long T1/2. but this drug is a weak mu-opioid receptor agonist

Answer 19

propoxyphene

Question 20

2 opioids to tx diarrhea?

Answer 20

loperamide and diphenoxylate

Question 21

2 opioid antagonists?

Answer 21

1. naloxone

2. naltrexone

Question 22

what drug is a competitive mu, delta, and kappa-opioid receptor ANTAGONIST?

Answer 22

naloxone

Question 23

what drug is used to tx alcoholism?

Answer 23

naltrexone

Question 24

mu-opioid antagonist

Answer 24

naltraxone

Question 25

1. can precipitate w/d (flu-like sx of n/v/d, piloerection, yawning, irritability);
2. need continuous prn infusion bc only lasts 15-30min. (oral form is completely metabolized by liver)
3. pt has normal mental status

Answer 25

naloxone

Question 26

may produce prolonged w/d state (n/v/yawning, piloerection)

Answer 26

naltrexone