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Eukaryotic Pathogens > Parastic Diagnostics And Therapies > Flashcards

Parastic Diagnostics And Therapies Flashcards

1
Q

Which tests detect antibodies?

A

ELISA
Agglutination

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2
Q

Which test detects antigens?

A

RDT (dipstick)

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3
Q

How does the RDT (dipstick) work?

A

Add sample and antibodies
Liquid is absorbed up stick
Passes antigen specific capture antibody
If positive the antibody tagged antigen will stick
Passes control which captures the antibodies
Two lines equal positive

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4
Q

Culture pros

A

Definitive

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5
Q

Culture cons

A

Delayed diagnosis
Lacks sensitivity

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6
Q

Microscopy pros

A

Easy
Quick

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7
Q

Microscopy cons

A

Technician training
Lacks sensitivity and specificity

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8
Q

Serology (antibody testing) pros

A

High specificity
Cheap and easy (CATT)
Quantitative (ELISA)

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9
Q

Serology (antibody testing) cons

A

False positives because it only tests for any exposure not current infection
No “pan-detection”

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10
Q

Antigen testing pros

A

Detects active infections
Quantitative (ELISA)
Cheap and easy (RDT)

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11
Q

Antigen tests cons

A

Lacks sensitivity
RDT is non-quantitative

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12
Q

Molecular PCR testing pros

A

Detects active infections
Quantitative (ELISA)
Sensitive (multi copy targets)

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13
Q

Molecular PCR testing cons

A

Technical and skill requirements
“Pan-detection” vs species

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14
Q

Leishmania treatments

A

Antimonials (inhibits replication)
Miltefonsine (inhibits replication)
Pentamidine (accumulates)
Ergosterol inhibitors (amphotericin and ketoconazole) (inhibit cell membrane production)

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15
Q

Toxoplasma treatments

A

Antifolates (pyrimethamine and sulfadoxine) (inhibits DNA replication)

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16
Q

Malaria treatments

A

Artemisinin (inhibits replication)
Quinines (inhibits hemozoin formation)

17
Q

Malaria prophylaxis

A

Antifolates (inhibits DNA replication)
Doxycycline

18
Q

T.b. gambiense treatments

A

Pentamidine (inhibits replication)
Eflornithine (inhibits cell growth and replication)

19
Q

T.b. rhodesiense treatment

A

Melarsoprol (aresenic)
Nifurtimox (ROS)

20
Q

Malaria vaccines

A

IV of irradiated sporozoites prevent Napa to the invasion (works well)
RTS,S pseudopathogen of CSP repeats (mild protection)

Eukaryotic Pathogens (15 decks)

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