Blastomyces Flashcards
1
Q
How do you find candidate factors?
A
mix antigens with patient serum that contains antibodies
2
Q
What does BAD1 stand for?
A
Blastomyces ADhesion 1
3
Q
What do BAD1 do?
A
- adhere to macrophage
- DOWN TNFalpha (proinflam) via secreted BAD1
4
Q
What does DRK1 stand for?
A
Dimorphic Regulating Kinase 1
5
Q
What do DRK1 do?
A
turns on BAD1 and allows blasto to turn into yeast
6
Q
How did they find DRK1?
A
looked for mutants that don’t express BAD1 but still grow