Coccidioides Flashcards
1
Q
Where is cocc found and hence its nickname?
A
San Joaquin Valley Fever
2
Q
Who are suceptible to disseminated disease?
A
- HIV+
- old fuckers
3
Q
spherule
A
- large ball with mini spherules inside
- eventually pops to release endospores
4
Q
How do you form endospores?
A
- spherule grows in lung
- replicates without cytokinesis
- nuclei eventually turn into their own endospore
- spherule pops to release them
5
Q
What does SOWgp stand for?
A
Spherule Outer Wall GlycoProtein
6
Q
What do SOWgp do?
A
binds to ECM tissues
7
Q
What does MEP1 stand for?
A
- MEtaloProtease 1
8
Q
What do MEP1 do?
A
removes SOWgp from endospores so they aren’t opsonized by antibodies
9
Q
Can cocc by recognized by TLRs, Dectin1, and MR?
A
no
10
Q
Can ROS control cocc?
A
no
11
Q
Can RNS control cocc?
A
no
11
Q
Can RNS control cocc?
A
no
12
Q
What is important to control cocc?
A
activating macrophages
13
Q
Is IFNgamma necessary and or sufficent?
A
yes to both
