parasites Flashcards

1
Q

what is a parasite

A

animal or plant living in or on another and drawing nourishment from it

diagnosis of parasitic disease involves exposure history, clinical pattern of illness, ID in stool, blood, tissues, indirect evidence (serology, detection or parasitic antigens, DNA

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2
Q

what is a helminth

A

WORM

reproduce SEXUALLY usually within the host

pre-adult stage = OVA and LARVAE that live within or external to the host

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3
Q

what are protozoa

A

SMALL, UNICELLULAR organisms

have a nucleus and functioning organelles
reproduce quickly and ASEXUALLY in the host

have have a sexual phase in another host or vector

sub groups are based on motility (i.e amoeba, flagellates, ciliates, sporozoa/amicomplexa)

some protozoa have life stages alternating between proliferative stages (trophozoites) and dormant cysts

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4
Q

what are protozoa cysts

A

dormant phase

can survive in harsh conditions

allow the parasitic special to survive without a host

allow for transmission

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5
Q

what are protozoa trophozoites

A

actively feeding METABOLIC form of the protozoa

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6
Q

what are ectoparasites

A

insects

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7
Q

list the 3 classes of parasites

A
  1. protozoa (one celled organisms)
  2. helminths (worms)
  3. ectoparasites (insects)
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8
Q

list the 3 classes of helminth

A
  1. cestodes (tapeworms)
  2. nematodes (roundworms)
  3. trematodes (flatworms/flukes)
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9
Q

list the 4 classes of protozoa

A
  1. amoeba
  2. ciliates
  3. flagellates
  4. sporozoans
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10
Q

what is a definitive host

A

host of a parasite where SEXUAL reproduction of the parasite occurs

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11
Q

what is an intermediate host

A

animal essential to the COMPLETION of the LIFE CYCLE of the parasite

transmission requires a reservoir and route of infection

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12
Q

nematode body

A

UNsegmented

bilateral symmetry

fully functional digestive tract

long and cylindrical

male and female worms

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13
Q

nematode sexes

A

separate

have male and female worms

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14
Q

nematode infection/transmission

A

eggs/larvae ingestion, skin penetration, arthropod vector

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15
Q

nematode lifecycle

A

eggs –> several larvae stages –> adult stage

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16
Q

list 7 nematodes

A
  1. necator americanus (hookworm)
  2. Loa Loa (filaria)
  3. Wucheria bancroft (filaria)
  4. onchocerciasis
  5. ascaris lumbricoides
  6. strongyloides stertocalis
  7. enterobius vermicularis
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17
Q

hookworm

A

nematode

necator americanus

LARVAL stage of worm penetrates SKIN –> usually through FOOT causing infection in the foot

once it penetrates the skin, it is carried through teh blood vessels

heavy infections can result in childhood anemia

SOIL TRANSMITTED helminth

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18
Q

Loa Loa (filaria)

A

nematode

EYE worm

adult conjunctiva migration

transient calabar swellings

diagnosis via serology, microfilaria on BLOOD SMEAR

transmitted via CHRYSOPS fly

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19
Q

Wucheria bancroft (filaria)

A

nematode

ELEPHANTITIS

very common in some tropical zones

early symptoms = fever, lymphadenitis, transient edema

late obstruction = chronic edema and skin changes caused by blocked lymphatics

transmitted via MOSQUITO

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20
Q

onchoceriasis (filaria)

A

nematode

RIVER BLINDNESS

NO blood invasion

major cause of blindness–> skin disease in Africa and Yemen

diagnosis based on serology, skin snip, nodule biopsy

transmitted with SIMULIAN fly

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21
Q

Ascaris lumbricoides

A

nematode

prototypical roundworm

notable for LUNG MIGRATION phase–> larvae are coughed up, swallowed and mature in gut

excreted eggs need to embryonate in specific environmental conditions in soil before becoming infective–> therefore direct person to person transmission is not possible

heavy infection may result in bowel obstruction

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22
Q

Strongyloides stertocalis

A

nematode

MINUTE roundworm

can replicate and completed ENTIRE LIFECYCLE within a HUMAN

infection can persist for a human lifetime

SOIL TRANSMITTED helminth and is often acquired from skin penetration

23
Q

Enterobius vermicularis

A

nematode

PINWORM

very common–> causes PRUTITUS ANI in kids

fecal-oral transmission

persists due to poor hygiene

eggs can persist in local environment

24
Q

cestode body

A

are TAPEWORMS

large, can be up to meters long

live attached to MUCOSA in SMALL INTESTINE of host

use SCOLEX to attach which is an attachment organ with 4 ventral suckers with or without hooks

structure = chain of segments (proglottids) + neck + scolex

25
cestode sexes
hemaphroditic
26
cestode infection/transmission
can live for decades infection is via egg/larvae ingestion
27
name a cestode
taenia solium (pork tapeworm) taenia saginatum is cow tapeworm dipnyllobotherium latum is from uncooked fish echinococcus is from sheep
28
taenia solium
cestode pork tapeworm causes NEUROCYSTOCERCOSIS most medically important tapeworm infection worldwide most common parasite of CNS most preventable cause of EPILEPSY results from undercooked PORK--> humans eat adult tapeworm from pork--> human excretes eggs--> if another human ingests the eggs, eggs hatch and turn into CYSTECERCI in tissues, including in the brain parenchymal disease (cysts--> degeneration--> calcification--> seizures) extraparenchymal disease (sub-arachnoid space, ventricles, spine) most important clinical goal is to CONTROL INFLAMMATION
29
trematode body
flatworms/flukes first intermediate host is SOIL second intermediate host is FISH/SHELLFISH dorso-ventrally flattened, unsegmented, leaf-like or cynindrical structure
30
trematode sexes
hermaphroditic
31
trematode infection/transmission
require 1 or more intermediate hosts infect through skin penetration or larvae ingestion
32
name 2 trematodes
1. paragonimus westermani | 2. schistosomiasis
33
paragonimus westermani
trematode LUNG fluke reservoir = wild and domestic carnivores usually asymptomatic--> can have COUGH (often confused with TB, lung cancer) rare cerebral disease diagnosis through serology, sputum (eggs), eosinophilia infection through LARVAE INGESTION
34
schistosomiasis
trematode BLOOD fluke cause of morbidity in Sub-Saharan Africa acquired by swimming in freshwater lake or rivers microscopic CERCARIAE burrow through skin and migrate to blood vessels surrounding target organs --> females lay eggs--> eggs penetrate into tissue through vessel walls --> eggs propelled into lumen --> pass in urine or stool ``` urogenital = S. haematobium intestinal/hepatic = S. mansoni, S. japonicum ``` acute infection is usually 4 weeks post-exposure and involves fever, diarrhea, eosinophilia continued egg-laying leads to chronic inflammation and then to cancers, cirrhosis
35
list 5 ectoparasites
1. scabies 2. head lice 3. body louse 4. trench fever (body louse) 5. bot fly (Dermatobium hominis)
36
which type of protozoa are intestinal protozoa
FLAGELLATE i.e GIARDIA lamblia ("beaver fever")
37
which type of protozoa are extraintestinal protozoa
PLASMODIUM (malaria)
38
list 3 diseases caused by protozoa
1. malaria 2. leishmania 3. giardia lamblia
39
malaria vector
FEMALE ANOPHELES night-biting MOSQUITO transmits through BITE
40
malaria species
``` P. falciparum P. vivax P. ovale P. malariae P. knowlesi ``` 50% = falciparum
41
malaria reproduction
asexual cycle in RBCs (SHIZOGANY) sexual reproduction in female anopheles mosquito (SPOROGANY)
42
malaria diagnosis method
thick and thin BLOOD SMEAR --> can determine species of plasmodium as well as % RBCs infected (parasitemia) rapid antigen tests
43
what is the most important parasitic disease
malaria--> #1 cause of fever in returning travellers
44
symptoms of uncomplicated malaria
``` fevers rigors headaches diarrhea nausea ``` may be mistaken for viral infection
45
symptoms of complicated malaria
from P. FALCIPARUM evidence of end-organ dysfunction (coma, renal failure) mortality is 10-20% with Tx
46
P. falciparum
infection is a medical emergency endemic in sub saharan africa parasites induces formation of sticky "KNOBS" on RBCs which clog small vessels in brain and lungs
47
P. falciparum versus P. vivax 1. dormant liver stage? 2. disease severity? 3. relapse? 4. asymptomatic carriage? 5. Tx
1. P. falciparum NO; P. vivax YES 2. P. falciparum 5% = severe; P. vivax risk of severe disease is not established 3. P. falciparum NO; P. vivax YES 4. P. falciparum = common; P. vivax very common 5. P. falciparum = arteminisin combo therapy; P. vivax = chloroquine + 14 days primaquine
48
Leishmania vector
sandfly
49
Leishmania species
L. donovani L. infantum L. chagasi (chagas disease)
50
Leishmania diagnosis
skin biopsy | serology
51
Leishmania Tx
amphotericin B topical ketoconazole
52
Leishmania clinical presentation
cause of ulcerated papule subclinical infection is most common HIV coinfection = reactivation fever, lymphadenopathy, hepatomegaly, progressive MASSIVE SPLENOMEGALY
53
giardia lamblia
intestinal protozoa (flagellate) most common GI intestinal protozoal infection in world fecal oral transmission may be asymptomatic causes GI symptoms by EFFACEMENT OF VILLI via inciting inflammation at the intestinal brush border this means that dietary FATS are absorbed poorly and result in "GREASY" STOOLS that FLOAT in the toilet NEVER INVASIVE on its own, and will NOT cause bloody diarrhea