antiparasites

Question 1

list the drugs that counter intestinal parasites

Answer 1

paromomycin (an aminoglycoside antibiotic)

i.e versus giardia lamblia, cryptosporidia, entamoeba histolytica

Question 2

name a drug used for ectoparasites

Answer 2

permethrin

Question 3

name 2 antihelminths

Answer 3

1. pyrantel pamoate

2. ivermectin

Question 4

paromomycin MOA

Answer 4

IRREVERSIBLY binds 30S ribosome

Question 5

paromomycin indications

Answer 5

intestinal parasites

Question 6

pyrantel pamoate MOA

Answer 6

cholinesterase inhibitor

Question 7

pyrantel pamoate indications

Answer 7

antihelminth

i.e against enterobius vermicularis and ancylostoma duodenale

Question 8

chloroquine MOA

Answer 8

antimalarial active int he ERYTHROCYTE phase

Question 9

chloroquine indication

Answer 9

P. falciparum/vivax/ovale/malariae/knowlesi

Question 10

atovaquone/proguanil MOA

Answer 10

anti-malarial active in the LIVER and ERYTHROCYTE phases

Question 11

permethrin MOA

Answer 11

alters NEURON SODIUM CHANNELS in ectoparasites causing paralysis and death

Question 12

ivermectin MOA

Answer 12

binds and activates GLUTAMATE-GATED CHLORIDE channels

Question 13

ivermectin indications

Answer 13

strongyloides stercoralis
ascaris lumbricoides
trichuris trichuria

anti-helminth

Question 14

what is the mazzoti reaction

Answer 14

a host inflammatory reaction to the death of parasites after drug administration

fever, hives, asthma, GI upset