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msk-derm > Papulosquamous Disorders > Flashcards

Papulosquamous Disorders Flashcards

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Dermatology Board Prep flashcards
1
Q

What are the most common sites for psoriasis?

A

Elbows, knees most common

can also occur in trunk, scalp, genitals

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2
Q

What is this?

A

Psoriasis

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3
Q

What condition does this describe: Thick scaly rash with silvery scale on elbows, knees

A

Psoriasis

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4
Q

What type of psoriasis covers the entire body and is red/scaly?

A

Erythrodermic psoriasis

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5
Q

What type of psoriasis primarily affects hands and feet?

A

Palmoplantar psoriasis

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6
Q

What is this?

A

Erythrodermic psoriasis

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7
Q

What are the effects of psoriasis on the nails?

A

Pits, onycholoysis (yellow discoloration)

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8
Q

What is this?

A

Psoriasis (note nail involvement)

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9
Q

What are the main features of psoriasis histology?

A

Elongated, thickened epidermis with rapid production of of keratinocytes, thick stratum corneum, proliferation and dilation of blood vessels near the surface

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10
Q

What is the image on the right?

A

Psoriasis histology (thick epidermis, thick stratum corneum, dilated blood vessels)

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11
Q

What is the age of onset of psoriasis?

A

It can start at any age of life, sometimes with a genetic factor and sometimes without

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12
Q

What is the pathophysiology ofpsoriasis?

A

It is an immune mediated condition with hyperproliferation that is driven by a cascade of inflammatory mediators with T cells and overexpression of TNF-alpha, IL-17, and IL-23 cytokines

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13
Q

What other conditions besides psoriasis are also driven by overexpression of TNF-alpha?

A

Joints: rheumatoid arthritis, psoriatic arthritis

GI system: Chrons disease/ulcerative colitis

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14
Q

What is guttate psoriasis?

A

A form of psoriasis with smaller, coin sized plaques that is often triggered by preceding sore throat, bacterial strep infection or viral infection

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15
Q

What skin condition can be triggered by a preceding sore throat, bacterial strep infection, or viral infection?

A

Guttate psoriasis

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16
Q

What is this?

A

Guttate psoriasis

17
Q

What are possible triggers for psoriasis?

A

Streptococci, stress, trauma, drugs (beta blockers, lithium)

18
Q

What drugs are most likely to trigger psoriasis?

A

Beta blockers, lithium

19
Q

What is this? Associated history: several months of lower back stiffness and early morning/periodic swelling of fingers and toes (“sausage fingers”)

A

Psoriatic arthritis

20
Q

What is psoriatic arthritis?

A

A type of immune mediated arthritis that may lead to destructive/disabling arthritis, morning stiffness, and dactylitis

21
Q

What amount of morning stiffness is associated with psoriatic arthritis?

A

Stiffness that improves 30 minutes to 1 hour after walking

22
Q

What cytokines are associated with psoriatic arthritis?

A

TNF-alpha

23
Q

What is the treatment for localized psoriasis?

A

High potency topical steroids (clobetasol, triamcinolone)

24
Q

What is the treatment for widespread psoriasis?

A

UV light phototherapy, targeted therapy with TNF-alpha, IL-23, and IL-17 blockers

25
Q

What is this? Associated history: not itchy, moisturizers are not helping.

A

Seborrheic dermatitis

26
Q

What is the appearance of seborrheic dermatitis?

A

Redness, and thin yellow (waxy) flaking around the nose, eyebrows, beard area, ears, hairline, scalp

27
Q

What is the cause of seborrheic dermatitis?

A

Overgrowth of yeast (pityrosporum ovale)

28
Q

What is the treatment for seborrheic dermatitis?

A

Antifungal creams, mild topical steroids

29
Q

What is this? Associated history: preceded by slight fever and cold-like symptoms.

A

Pityriasis rosea

30
Q

What is pityriasis rosea?

A

Oval salmon colored thin macules or patches with thin scale mostly affecting the trunk, acute self resolving process, often begins with a herald patch

31
Q

What condition often begins with a “herald patch”?

A

Pityriasis rosea

32
Q

What condition often presents with a “christmas tree” pattern on the back?

A

Pityriasis rosea

33
Q

What is the etiology of pityriasis rosea?

A

Possible reactivation of HHV 6 or 7

34
Q
A

msk-derm (41 decks)

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