Paper3 Schizophrenia Flashcards
Positive symptoms
Additional experience
Negative symptoms
Loss of usual ability
Hallucinations
Sensory experience of things that aren’t there
Delusions
Irrational beliefs of grandiose or religion or paranoia
Speech disorganisation
Changing topic of conversation quickly
Catatonia
Unusual movement
Flat affect
Lack of emotional expression
Avolition
Lack of motivation
Polygenic
Two or more genes determine disorder
Aetiologically heterogenous
Number of different combinations of genes that lead to illness
RIPKE(2014)
108 genetic loci associated with schizophrenia
Suggests aetiologically heterogenous disorder
External reliability
Consistency of results from test when repeated
Inter rater reliability
Consistency of investigators observing study
Validity of schizophrenia
Extent to which it is a syndrome with specific characteristics or mixture of other disorders
Validity of diagnosis
Are we correctly diagnosing disorder
BUCKLEY
Simultaneous presence of disorders with schizophrenia
50% depression
20% OCD
Candidate Gene
Chromosomal location associated with disease
Genetics
Study of genes
Carry information from one generation to another
Neutral correlates
Brain activity corresponds with behaviour
Dopamine
Neurotransmitter for pleasure
Concordance rate
Percentage of cases where both members of a pair have a particular attribute
Genetic counselling
Understanding genetic illness and how it effects family
Polygenic
Phenotype influenced by more than one gene
Superior temporal gyrus
Attributes stimuli to internal and external causes of schizophrenia
Activity levels are lower leading to hallucinations
Ventral striatum
Anticipation of reward
Low activity on schizophrenics so loss of motivation
Antipsychotics
Medication controls delusions and hallucinations
Typical antipsychotics (first generation)
Severe side effects
Dry mouth
confusion
Reduced dopamine
Atypical antipsychotics (second generation)
Blocks dopamine receptors
Acts on other neurotransmitters like serotonin
Addresses negative symptoms
Side effects of weight gain
Prefrontal Cortex
Logical thinking
So disorganised thoughts due to low activity in schizophrenics
Visual cortex and auditory cortex
Processes info received by eyes and ears
So auditory hallucinations
Basal ganglia
Affects movement and thinking skills
So motor dysfunction due to larger size in schizophrenics
Amygdala
Responsible for fear and lust and hunger
So loss of emotion due to smaller size in schizophrenics
Delay discounting
Depreciation of value of a reward to time it takes to be released
Auditory selective attention
Focus on certain stimuli to process info while disregarding other stimuli
Alien control symptoms
Feelings of control are lost by Szic patient
Meta representation
Reflecting on thoughts and behaviour and to know the intentions
Token economy
Reward good behaviour with token that can be exchanged for desire
Central control
RELEVANT STUDY: Stirling Stroop Test
Suppress automatic responses while performing deliberate action
Dysfunctional thought processing
Understanding and perception of the world
Emotional over involvement
Excessive worry/ self sacrifice/ concern
Expressed emotion
RELEVANT STUDY: Bootzlaff + Hooley
Family dynamic
Hostility, criticism, EOI
Double bind
Communication style that has opposing message
Disorganised thinking and paranoia
Schizophrenic mother
Cold and rejecting
Psychotic thinking, delusions
Family dysfunction
RELEVANT STUDY: Tienari
Sz symptoms due to family relationships
Trice dyskinesia
Antipsychotic drugs cause this
Rapid and jerky movement
Dopamine antagonist
Block dopamine receptors eg) chlorpromazine
Dependency
Predisposition to addiction of schizophrenic
Hyperdopaminergia
Too much dopamine
Hypodopaminergia
Too low dopamine
Excitatory
Promotes action potential
Inhibitory
Inhibits action potential
Neural correlates
Distribution of brain activity and biochemistry increasing risk of Sz
Dopamine hypothesis
RELEVANT STUDY: Leucht
Hyperactivity of D2 receptor
Positive symptom of Sz
Prevalence
Proportion of population who have a disorder
D2 dopamine receptor
Sleep, learning, attention, memory