Pancreas II: CF, Cystic Disorders and Cancer Flashcards

1
Q

What are the main symptoms of CF?

A

lung infections, chronic pancreatitis, hypertonic sweat

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2
Q

What is the gene defect in CF

A

caused by a threebase pair deletion deltaF508 that affects the folding, processing and functioning of the CF gene product, the cystic fibrosis transmembrane conductance regulator.

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3
Q

Explain the pathophys of CF

A

defective chloride secretion
inspissated secretory product
obstruction of ducts and lumens
infetion, inflammation and tissue destruction

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4
Q

What are clinical manifestations of CF

A
obstructive/inflammatory lung dz
chronic pancreatitis
hypertonic sweat ( because no reabso of cl)
hepatobiliary tract dz
meconium ileus in infants
infertility
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5
Q

What can be seen of ducts on histo in CF

A

several distended with dark pink secretions

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6
Q

What are clinical symptoms of CF

A

frequent pulmonary infections (pseudomonas)
diarrhea, malabsortion, failure to thrive bc no acinar cells
frequent episodes of dehydration

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7
Q

What are benign pancreatic cysts

A

pseudocysts

rare non-neoplastic cysts

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8
Q

What are cystic neoplasms of pancreas

A

serous cystic tumors
mucinous cyst neoplasms
intraductal papillary mucinous neoplasms
solid pesudopapillary neoplams

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9
Q

what are potentially malignant cystic lesions

A

mucinous cystic neoplasms
intraductal papillary mucinous neoplasms
solid pseudopapillary neoplasms

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10
Q

What type are the majority of pancreatic cancers?

A

adenocarcinomas of ductal origin

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11
Q

what are the common presentations of pancreatic cancer?

A

adb pain and weight loss

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12
Q

What is it called when pancreatic cancer results in the lack of gland formation

A

anaplasia

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13
Q

what are risk factors for pancreatic cancer

A

cigarette smoking
alcohol in setting of CP
hereditary pancreatitis
family hx

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14
Q

What are clinical features of pancreatic adenocarcinoma?

A

weight loss, abdominal pain and jaundice (from cbd obstruction)

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15
Q

What is a serum marker elevated in pancreatic adenocarcinomas?

A

CA19-9

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16
Q

where is the best place to have pancreatic cnacer?

A

in the head of the pancreas (which is also the most common location

17
Q

67 yo wm smoker with weight loss and vague abd pain over 3 mos. yellow sclera. most concerned he has?

A

a mass in head of pancreas

think 60-70s male smoke with yellow eyes