Malabsorption Pathology Flashcards

1
Q

What is a characteristic histologic pathologic finding of malabsorption due to celiac sprue/gluten-sensitive enteropathy?

A

villous blunting

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2
Q

What do you see in the epithelium on histology in celiac sprue?

A

intra-epithelial CD8 lymphocytes, not normally located in epi. so their presence here is suggestive of problems

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3
Q

Explain the molecular pathology of celiac sprue - gluten-sensitive enteropathy

A

APC cells to CD4 cells, immune response with CD8 intraepithelial lymphocytes and CD4 lamina propria cells

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4
Q

What genetic mut is common in gluten-sensitivity?

A

95% have HLA-DQ2, while the remainder have DQ8

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5
Q

T or F: viral gastroenteritis can cause temporary dissacharidase deficiency

A

true

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6
Q

What is whipple disease?

A

rare intestinal lymph nodal, cerebral cardiac and joint infection with tropheryma whippellii

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7
Q

what is tropheryma whippelii

A

the rare bacteria leading to whipple dz, a PAS-stain positive actinomycetere, presenting as purple bacilli

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8
Q

Who presents with whipple dz?

A

late middle-aged white males

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9
Q

Who commonly has lactase deficiency?

A

adults, AAs

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10
Q

What breath test can you do to detect lactase deficiency?

A

Breath hydrogen levels becuase of the xs cho in lumen due to bacterial overgrowth

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11
Q

What is ascaris?

A

roundworm infection

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12
Q

What is your ddx for malabsorption syndrome?

A

gluten-sensitive enteropathy
chronic pancreatitis
zebras

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13
Q

what malabsorption syndrome is associtated with type i diabetes?

A

gluten-sensitive enteropathy

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14
Q

24 yo wm from wisscons with diarrhea T41.2, orthostatic hypotension, malaise, fatigue, doesn’t eat for week. Recovers then drinks milk. Problem returns, due to:

A

lactase deficiency

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15
Q

64 bm musician 10 lb weight loss, insidious steatorrhea, recent hospitalization for abdominal pain and retroperitoneal calcifications behind mid and luq abdom due to:

A

???? my guess, chronic pancreatitis

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16
Q

24 yo wf chronic diarrhea and hosp for abd pain. short think and pale. due to:

A

celiac sprue

17
Q

24 latina farmer from mexico 10 weight loss, chronic diarrhea hospitalized for abd pain. hgb 4, plts 500 wbc 15, with 75 segs, 5 bands, 10 eos, 6 lymphocytes and 4 monos. due to:

A

ascarias (because eos which are not present in giardia)