GI Motility Disorders Achalasia Flashcards
What does the enteric nervous system consist of?
the myenteric plexus and the meissner pelxus
what are the pacemaker cells?
interstitial cells of cajal located in the greater curvature of the antru
what is the enteric excitatory neuron?
ach and sub p
what is the inhibitory enteric neurons
vip/no
LES relaxation is controlled by?
vagus, no mediated
what conditions will affect the striated muscle of the esophagus/
polymyositis
myasthenia gravis
What conditions affect smooth muscle of esophagus?
scleroderma
achalsia
What is primary peristalsis?
reflex esophageal peristaltic contraction wave associated with swallowing
what is secondary peristalsis?
residual food in esophagus cleared by this
what is a key function of the migrating motor ocmplex?
housekeeping for bacteria
what is achalasia?
achalasia means doesn’t relax,
what is the etiology of achalaisa?
AI, degenerative, infxs
what is lost in achalasia?
post-ganglionic inhibitory neurons
what is seen on pathology of achalasia?
lymphocytic infiltrate in myenteric pelxus and loss of ganglion cells
What are symptoms of achalasia?
dysphagia for solid and liquid
chest pain around xiphoid process
heart burn weight loss regurg of food
