Pain Management Flashcards
Pain
An adverse sensory and emotional experience
Nociception
Perception of pain by the nervous system
* processed similarly in all mammals
4 Stages of Nociception
- Transduction
- Transmission
- Modulation
- Perception
Transduction
Conversion of mechanical energy into electrical energy (nerve impulses)
Transmission
Nerve impulse conducted along peripheral nerves leading to spinal cord
Modulation
Change in nerve impulse
- impulses modified once in spinal cord
- amplified or suppressed
- advanced along spinal cord to brain once finished
Perception
What and where it occurs
Impulse processed and recognized as pain
*occurs in Thalamus
Pain & The Brain
Pain free region of the body
* no sensory nerves
Tissue Sensitivity to Pain
Degree of tissue sensitivity to pain is related to density of pain recepors present
Areas with High Density of Pain Receptors
- Skin
- Periosteum
- Joint capsule
- Muscle tendons
- Arterial walls
Area with Low Densitity of Pain Receptors
Visceral and Thoracic Organs
* few sensory nerves
* visceral pain vague, hard to localize
Cardinal Signs of Inflammation
- Pain
- Heat
- Redness
- Swelling
- Loss of function
Clinical Signs of Pain
- Increased HR and BP
- Peripheral vasoconstriction
- Pale MM
- Rapid breathing or panting
- Mydriasis
Perioperative Analgesia
- Provide analgesia surrounding time of surgery
- Multimodal Therapy & Preemptive Analgesia
Multimodal Therapy
- Treating more than one pain receptor site at same time*
- Prefered over using a single analgesic
- Lower dosages used
- Wide margin of safety
*using opioid and NSAID same time
“Wind up”
- CNS hypersensitivity
- Occurs with untreated, moderate-severe pain
“Wind up” Cause
Occurs when spinal cord neurons receive constant or longer term input from pain nerve fibers
* neurons become hypersensitive and hyperexcitable
NMDA
- N-methyl-D-aspartate
- Receptor that is activated in the spinal cord (hypersensitive)
Ketamine
And Wind-Up
- Prevent “wind up”
- Analgesic
- Block NMDA receptor
CRI
Constant Rate Infusion of analgesics
* method of treating constant pain
* IV drip to administer mixture of analgesics
* Can be added to bag of IV fluids
CRI Medications
- Morphine
- Ketamine
- Lidocaine
Opioids
- Analgesic
- Narcotics
Narcotics
Safety
Safest and most effective analgesic group available
Opiods
How They Work
Act at specific opioid receptors in CNS
* most activity in brain and spinal cord
Opioid Receptors
Categories
- Mu
- Kappa
- Sigma
- Delta
- Epsilon
Morphine
Agonist
- Mu agonist
- Produces very effective pain control
Buprenorphine
Agonist
- Mu agonist
- Not as effective as morphine
Agonists
Agonists stimulate the recepors for effect
Antagonists
Antagonists block opioid receptors for effect
* will act as a reversal agant*
EX: naloxone or nalorphine
Agonists and Antagonists
Mixed
Will stimulate some receptors and block other receptors
* allows for analgesia while reducing addiction potential
Butorphanol
Mixed Agonist/Antagonist Classifications
- kappa agonist
- mu antagonist
Butorphanol
Analgesic
- Will reverse analgesic effect of morphine
- Acts as an analgesic, but not as effective as morphine
Narcotics
Side Effects
- Panting
- Respiratory depression (in high doses)
- Bradycardia
- GI tract stimulation