Inhalation Anesthetics Flashcards
Inhalant Anesthetics
- Liquid agents vaporized in oxygen
- Administered via anesthetic breathing system by ET-tube, mask, or chamber
How are inhalant anesthetic agents measured
- Vapor pressure
- Blood-gas partition coefficient
- Minimum alveolar concentration (MAC)
Vapor Pressure
Measurement of the tendency of a liquid to evaporate
Vapor & Evaporation
Regarding Inhalant Agents
High vapor pressure = readily evaporate
* reach dangerously high concentrations
* administer using agent-specific precision vaporizer
Low vapor pressure
* may be administered with nonprecision vaporizer
Blood-gas Partition Coefficient
Measurement of the tendency of an agent to dissolve in blood
Blood-gas Partition Coefficient
Associations
- Speed of induction
- Recovery
- Change in depth of anesthesia
Low vs High Blood-gas Partition Coefficient
In regards to speed of induction, recovery, and change in depth of anesthesia
Low Partition Coefficient = Faster
High Partition Coefficient = Slower
MAC
- Minimum Alveolar Concentration
- Percent concentration of an agent
- Measurement of potency of agent
High vs Low MAC
High MAC = less potent
* more required to attain surgical anesthesia
Halogenated Anesthetics
Function and Causes
- Induce and maintain general anesthesia
- CNS depression
- Respiratory depression
- Hypothermia
- Hypotension
- Muscle relaxation
- No analgesic postoperatively
Halogenated Anesthetics
Examples
- Isoflurane
- Sevoflurane
Halogenated Anesthetics
& the Heart
Cause myocardial depression
* cardiac function maintained close to preanesthetic levels
Iso & Sevo
Vapor Pressure and Blood-gas Partition Coefficients
Both have:
* High vapor pressure - need precision vaporizer
* Low blood-gas partition coefficients - rapid induction, recovery, and change in anesthetic depth
Halogenated Anesthetics
Metabolism and Excretion
Both metabolized in Liver
Excreted primarily through lungs, but also by kidneys
Iso & Sevo
Metabolism
Metabolized by liver
Iso = better choice for those with kidney or liver disease
Sevoflurane and Fire/Heat
- Fire / heat production produced when used with dry CO2 absorbent
- More common when low oxygen flow rates used over long time
Sevoflurane and Fire/Heat
Preventions
- Turn machine off when not in use
- Replace absorbent granules regularly
- Avoid low oxygen flow rates for extended periods
- Monitor temperature of abosrbent canister
Desflurane
- Similar to Isoflurane
- Extremely high vapor pressure
- Low blood-gas partition coefficient
Desflurane
Vaporizer
Required expensive electronic vaporizer
* boiling point is near room temperature