page 320-329 Flashcards

1
Q

Lesion on one side causes

A

Ipsilateral motor loss (corticospinal).

■ Ipsilateral touch/sensory loss.

■ Contralateral pain and temperature loss (spinothalamic).

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2
Q

https://drive.google.com/open?id=0B8uJUY-tie8GU1RKaGFxb05MTzQ

A

https://drive.google.com/open?id=0B8uJUY-tie8GRENDaFRSdWZnakk

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3
Q

——– set up across the resting nerve membrane.

■ Due to separation of charged particles (ions and proteins) between

extracellular and intracellular fluids.

A

Charge differential or voltage set up across the resting nerve membrane.

■ Due to separation of charged particles (ions and proteins) between

extracellular and intracellular fluids.

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4
Q

Polarized membrane■ ).

A

More positive ions (cations) outside (extracellular).

■ More negative ions (anions) inside (intracellular

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5
Q

Charge separation occurs because:

xxx leak (resting K+ conductance)

yyyyy charges leave cell down electrochemical gradient.

■zzzz zzzz determinant of RMP.

A

Charge separation occurs because:

■ K+ leak (resting K+ conductance)

■ + charges leave cell down electrochemical gradient.

■ Most important determinant of RMP.

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6
Q

Na+/K+ pump

■ Using ATP, establishes the x and y gradient; creates gradient to

allow zz leak to occur.

■ Pump is electrogenic: a K+ in for every b Na+ pumped out = net loss

of c charges from the cell.

A

Na+/K+ pump

■ Using ATP, establishes the Na+ and K+ gradient; creates gradient to

allow K+ leak to occur.

■ Pump is electrogenic: 2 K+ in for every 3 Na+ pumped out = net loss

of + charges from the cell.

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7
Q

RMP: ranges between a and b

■ RMP in humans (most cells) is xxxx (close to K), skeletal muscle

yyyyy, cardiac muscle zzzz

■ Threshold for depolarization: ~ tttt

A

RMP: ranges between –40 and –85 mV.

■ RMP in humans (most cells) is ~ –70 mV (close to K), skeletal muscle

–90 mV, cardiac muscle –90 mV

■ Threshold for depolarization: ~ –50 mV

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8
Q

Initiated by depolarizing stimulus (depolarization).

A

AP

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9
Q

RMP becomes more positive (less negative).

A

■ Ion channels open.

■ Positive ions move from outside to in.

■ As positive ions go intracellularly, RMP becomes positive.

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10
Q

Na+ (sodium)

A

■ Na+ entry initially causes more Na+ channels to open.

■ Membrane potential approaches that of sodium equilibrium potential.

■ Once threshold reached, the action potential (AP) will fire.

■ Threshold = 20 mV+.

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11
Q

All or none phenomenon.

A

■ If don’t reach threshold, don’t get AP.

■ AP is same with supra threshold and threshold stimuli

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12
Q

REFRACTORY PERIOD

A

■ Period of time after an AP that the membrane cannot again be stimulated,

ie, another AP cannot be initiated

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13
Q

ABSOLUTE REFRACTORY PERIOD

A

■ No stimulus, no matter how large, will stimulate an AP (corresponds to

close of voltage-sensitive Na+ channel).

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14
Q

RELATIVE REFRACTORY PERIOD■

A

A larger than usual stimulus will stimulate an AP, ie, the threshold is

increased (due to increased permeability to K+ channel).

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15
Q

Repolarization (Figure 10–5)

A

■ Membrane potential returns to normal following an AP.

■ ↓ Na+ permeability (rapid).

■ Block Na+ entry.

■ ↑ K+ permeability (in to out)(slower).

■ K+ leaks out of the cell.

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16
Q

https://drive.google.com/open?id=0B8uJUY-tie8GaXBwV21SRWRNTEU

A

https://drive.google.com/open?id=0B8uJUY-tie8GaG55MVVkcWJXUjg

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17
Q

Hyperpolarization

A

■ During repolarization there is an overshoot in the more negative direction.

■ Membrane potential briefly becomes more negative than RMP before

returning to RMP.

■ This is because of ↑ K+ conductance.

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18
Q

This is because of ↑ K+ conductance.

■ K+ channels stay open.

■ K+ efflux is greater than in resting.

A

hyperpol.

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19
Q

Note: Hyperpolarization is responsible

A

for the relative refractory period (cell

remains hypoexcitable). Influx of Cl– will also hyperpolarize and make AP

more difficult to generate.

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20
Q

Block sodium channels (↓ Na+ permeability).

A

■ Bind to inactivation gates of fast, voltage-gated Na+ channels,

■ keeping them closed and

■ prolonging absolute refractory period.

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21
Q

↓ Membrane excitability → cannot generate AP → no nerve impulse

conduction.

A

■ Reversible.

■ K, Cl, Ca conductances are unchanged

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22
Q

LA

A

Affect small myelinated fibers first (size rule).

Unmyelinated C-fibers (slow, dull, long lasting) (smallest)

Small myelinated nerve fibers (pain, temp)

Larger A-fibers (touch proprioception, Golgi tendon)

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23
Q

Depolarize (more positive) the postsynaptic membrane potential.

■ Brings it closer to threshold.

■ ↑ probability of AP in postsynaptic neuron

A

excitability

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24
Q

Creates an excitatory postsynaptic potential (EPSP).

■ Glutamate is the major excitatory neurotransmitter.

A

excitability

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25
Q

Inhibitory

A

■ Hyperpolarize (more negative) the postsynaptic membrane potential.

■ Moves it away from threshold.

■ ↓ probability of AP in postsynaptic neuron.

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26
Q

Creates an inhibitory postsynaptic potential (IPSP).

■ Result of ↑ membrane permeability to either Cl– or K+.

A

inh

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27
Q

glycine

GABA.

■ Both bind receptors and open Cl– channels (↑ Cl– permeability

A

inh

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28
Q

Spatial Summation

A

■ Two excitatory inputs arrive at a postsynaptic neuron simultaneously.

■ Converging circuit.

■ Arrival of impulses from multiple presynaptic fibers at same time.

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29
Q

Temporal Summation

A

■ Two excitatory inputs arrive at a postsynaptic neuron in rapid succession.

■ ↑ frequency of nerve impulses from a single presynaptic fiber.

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30
Q

Nerve impulse =

A

action potential spreads along plasma membrane.

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31
Q

Occurs in myelinated fibers (remember: Schwann cells (periphery) and

oligodendrocytes (CNS)).

■ ↑ velocity of nerve transmission along myelinated fibers.

A

Salt conduction

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32
Q

salt conduction

A

Conserves energy because:

■ Only the Ranvier node depolarizes.

■ Less energy for Na+/K+ ATPase to reestablish resting ion gradients.

■ Na+/K+ pumps reestablish concentration gradient only at Ranvier

nodes.

■ Allow repolarization to occur with less transfer of ions.

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33
Q

Electrochemical basis behind saltatory conduction is xx membrane

capacitance (yyyy distance between charges; zzz charges necessary).

A

Electrochemical basis behind saltatory conduction is ↓ membrane

capacitance (increase distance between charges; less charges necessary).

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34
Q

MYELIN■

A

Prevents movement of Na+ and K+ through the membrane.

■ Na+, K+ conductance only at Ranvier nodes.

■ ↓ membrane capacitance.

■ ↑ membrane resistance.

35
Q

NODES OF RANVIER

A

■ Exposed nerve membrane where depolarization occurs.

■ Continue fueling spread of AP during nerve transmission.

36
Q

nodes of ranvier

A

■ Located every 0.2–2 mm along the myelin sheath.

■ APs could not be produced if the myelin sheath were continuous.

■ APs travel down axon and “jump” from node to node.

37
Q

CONTINUOUS CONDUCTION

A

■ Occurs in unmyelinated fibers.

■ Nerve transmission (AP) travels along entire membrane surface.

■ Relatively slow conduction (1.0 m/sec).

38
Q

WALLERIAN DEGENERATION

A

■ Axon is cut.

■ The axon remnant distal to the cut (away from the cell body) degenerates

because axonal transport is interrupted.

39
Q

wallerian degen.

A

■ Regeneration of axons possible if endoneurial sheath is intact (neurolemma).

■ Occurs at a rate of 2–4 mm/day.

■ If cell body is irreversibly injured, the entire neuron degenerates.

40
Q

NEUROPRAXIA

A

■ Transient block (bruise).

■ Incomplete paralysis or loss of sensation.

■ Rapid recovery.

41
Q

AXONOTMESIS

A

■ Axon damaged, but connective sheath remains intact.

■ Wallerian degeneration occurs distally but then regeneration can occur.

42
Q

NEUROTMESIS

A

■ Complete transaction of nerve trunk.

■ Results in:

■ Motor

■ Flaccid paralysis.

■ Atrophy of end-organ.

43
Q

Sensory

■ Total loss of cutaneous sensation.

A

NEUROTMESIS

44
Q

synapse

A

Functional connection, anatomical junction between

■ Nerve axon (presynaptic axon) and

■ Target cell

■ Nerve (postsynaptic neuron)

■ Muscle (NMJ)

■ Gland

Synapse controls direction of nerve impulse

45
Q

PRESYNAPTIC NEURONS

A

■ Transmit information toward a synapse.

46
Q

SYNAPTIC CLEFT

A

■ Space between presynaptic terminal and postsynaptic cell.

47
Q

POSTSYNAPTIC NEURONS

A

■ Transmit away from a synapse (dendrite → axon).

48
Q

NERVE IMPULSES

A

■ Travel in only one direction because synapses are polarized.

49
Q

Neuronal Excitability

A

■ Nerves are excited (APs generated) electrically or chemically.

■ Ligand-gated (NT binding) (most common).

■ Voltage-gated channels.

■ Mechanically gated (stretching).

50
Q

Types of Synapse

A

■ Chemical synapse (most common).

■ Ligand-gated: Use NTs.

■ Electrical synapse.

51
Q

CHEMICAL SYNAPSE.

A

■ Most common type.

■ Consists of:

■ Presynaptic membrane.

■ Synaptic vesicles within this terminal contain a NT.

■ Synaptic cleft.

■ Space between the presynaptic and postsynaptic membranes.

■ Postsynaptic membrane.

■ Membrane of postsynaptic neuron that contains specific receptors

for the NT

52
Q

SYNAPTIC TRANSMISSION

A

■ Release of NTs.

■ NTs are stored in synaptic vesicles within the presynaptic axon terminal.

■ AP depolarizes the presynaptic membrane, causing:

■ Voltage-gated Ca2+ channels opened (on the presynaptic membrane).

■ ↑ Ca2+ influx.

53
Q

synaptic transmission

A

■ Ca2+ causes the synaptic vesicles to fuse with membrane.

■ NTs are released by exocytosis into synaptic cleft.

■ NTs diffuse across cleft.

■ Bind to specific receptors on postsynaptic cell.

■ The time required for this process to occur is called synaptic delay.

54
Q

Mediate most connections.

■ Small molecule NTs (contained within vesicles):

■ Glutamate, GABA, glycine, ACh, 5HT, NE, Epi, etc.

A

chemical NT

55
Q

Neuropeptides (large dense vesicles):

■ Somatostatin, endorphins, enkephalins, opioids, etc.

A

chemical NT

56
Q

ELECTRICAL SYNAPSE

A

■ Gap junctions; minority.

■ Cytoplasm of adjacent cells is connected by gap junctions.

57
Q

electrical synapse

A

Allows passage of local electrical currents (ions and small molecules)

(from APs in presynaptic neuron) to pass directly to postsynaptic neuron.

■ Rare in the CNS.

■ Common in cardiac and smooth muscle.

■ Ensure a group of neurons act together; Synchronize groups of

neurons.

■ Important in embryonic development (morphogenic gradients

58
Q

NM junction

A

Synapse between lower motor neuron (efferent nerve) and muscle.

■ Presynaptic terminal (lower motor neuron axon)

■ Releases ACh.

■ Postsynaptic membrane (skeletal muscle membrane).

■ Displays nicotinic receptor (NM).

59
Q

NM junction

A

Threshold is –65 mV → all or nothing!

■ ~35 ACh required.

60
Q

https://drive.google.com/open?id=0B8uJUY-tie8GRlZyMlp1OGdyeE0

A

https://drive.google.com/open?id=0B8uJUY-tie8GSF9nS3IwQkJyNFE

61
Q

Acetylcholine Metabolism

A

■ Synthesized in the presynaptic terminal of the motor neuron from which

it is released.

■ Acetyl CoA + choline – (choline acetyltransferase)→ ACh (acetylcholine).

62
Q

Ach metab.

A

Stored in synaptic vesicles.

■ Released into synaptic cleft (generates effect).

■ Breakdown:

■ ACh – (acetylcholinesterase [AChE])→ acetate + choline.

63
Q

ant eyeball

A

Consists of two chambers (anterior and posterior).

■ Filled with aqueous humor (watery fluid).

64
Q

pst eyeball

A

Posterior segment

■ Filled with vitreous humor (thick, gelatinous material

65
Q

Sclera■

A

Tough, white outer layer.

■ Maintains size and form of the eyeball.

66
Q

Cornea

A

■ Transparent dome on the anterior eye surface.

■ Protective function.

■ Helps focus light on retina at back of eye.

67
Q

Choroid

A

■ Lining of the inner aspect of the eyeball beneath the retina; very vascular

68
Q

Pupil

A

■ Circular opening (black area) in the middle of the iris.

■ Light enters the eye to reach retina through this opening.

■ Lens is located behind this aperture.

■ Size of the pupil is controlled by muscles in the iris.

69
Q

Iris

A

■ Circular colored area of the eye (amount of pigment in the iris determines

the color of the eye).

70
Q

Miosis:

A

Constriction of pupil:

■ Sphincter pupillae (iris sphincter) closes iris.

■ Response to:

■ Increased light.

■ Drugs (eg, narcotics).

■ Pathologic conditions.

■ Parasympathetic stimulation.

71
Q

Mydriasis:

A

Dilation of the pupil (term often used for prolonged papillary

dilation):

72
Q

Dilation of the pupil (term often used for prolonged papillary

dilation):

A

Mydriasis

73
Q

Dilator pupillae (iris dilator) opens iris.

■ Response to:

■ Decreased light.

■ Sympathetic stimulation (fight or flight).

■ Drug.

■ Disease.

A

Mydriasis

74
Q

Lens

A

■ Directly behind the iris and pupillary opening.

■ Focuses light on the retina.

■ Controlled by ciliary muscle (within the ciliary body).

75
Q

Ciliary body

A

■ Functions:

■ Accommodation.

■ Ciliary muscle alters the lens refractory power (to focus light on the

retina).

■ Produces aqueous humor.

■ Holds lens in place

76
Q

Retina

A

■ Innermost layer of the eye on the posterior surface.

■ Receives visual stimuli.

■ Communicates via CN II with the brain (visual cortex).

■ Photoreceptors

77
Q

Rods (higher sensitivity, lower acuity)

A

■ Contain rhodopsin (photopigment).

■ Perceive different degrees of brightness: Responsible for night

vision (dark adaptation).

■ Relative lack of color discrimination.

■ Located mostly at the periphery of the retina.

78
Q

Cones (higher acuity (fovea); color)

A

■ Each contains one of three photopigments.

■ Each being sensitive to a particular wavelength of light.

79
Q

Three types: Red, green, blue.■

A

Primarily responsible for color vision.

■ Principal photoreceptors during daylight or in brightly lit areas.

■ Located in the center of the retina, especially in the fovea.

80
Q

Photopigments

A

■ Four photopigments:

■ Rhodopsin (rods).

■ Red, green, and blue (cones).

81
Q

Each photopigment contains:

A

■ Opsin (protein) bound to

■ Retinal (a chromophore molecule).

■ Together they compose rhodopsin.

82
Q

Photopigments

The difference among the opsin molecules allows a xxx to

have yyyyy for a particular type or zzzz of light

A

Photopigments

The difference among the opsin molecules allows a photopigment to

have specificity for a particular type or color of light

83
Q

https://drive.google.com/open?id=0B8uJUY-tie8GUm5DNlBIQndXbGs

A

https://drive.google.com/open?id=0B8uJUY-tie8GclUwQkFPUmdHVzA