P5 PATHOLOGY

Question 1

Composition of articular cartilage

Answer 1

• chondrocytes
• intercellular matrix

Question 2

Composition of subchondral bone plate

Answer 2

Coarse cancellous Bone

Question 3

function of subchondral bone plate

Answer 3

Maintenance of articular cartilage

Question 4

most prominent type of collagen seen in articular cartilage

Answer 4

type 1

Question 5

Link proteins, hyaluronic acid and glycosaminoglycans
Bind large amount of water is a function of

Answer 5

Proteoglycans

Question 6

Chronic non-inflammatory slowly progressive degenerative destructive degradation of the articular cartilage of weight bearing joints is known as

Answer 6

Osteoarthritis

Question 7

features of osteoarthritis ( classic triad )

Answer 7

• joint narrowing
• subchondral bone thickening
• osteophytosis

Question 8

aetiology of primary osteoarthritis

Answer 8

Intrinsic defect in the articular cartilage

Question 9

Primary OA sequences

Answer 9

1- DAMAGE
2- repair attempts
3- failure of repair

Question 10

list the articular changes in order

Answer 10

1- flaking
2- clustering
3-Fibrillation
4-abrasion
5- Neovascularisation

Question 11

Exposure and sclerosis of subchondral bone trabeculae in areas of cartilage loss is called

Answer 11

eburnation

Question 12

re- growth of articular cartilage is known as

Answer 12

osteophytes

Question 13

showing gross images of femoral epiondyle
Identify what is 4

Answer 13

loss of C & O shaped menisci

Question 14

showing gross images of femoral epiondyle
Identify what is 8

Answer 14

eubernation of subchondral bone

Question 15

showing gross images of femoral epiondyle
Identify what is 7

Answer 15

sclerotic subchondral bone

Question 16

showing gross images of femoral epiondyle
Identify what is 5& 6

Answer 16

irregular patches of partial and complete loss articular cartilage
exposure of subchondral bone

Question 17

histology of late changes OA
Identify what is 5

Answer 17

Fibrocartilaginous plug extending from marrow onto joint surface

Question 18

histology of late changes OA
Identify what is 6

Answer 18

Eubernated bone

Question 19

histology of late changes OA
Identify what is 9

Answer 19

subchondral bone cyst

Question 20

histology of late changes OA
Identify what is 10

Answer 20

reactive bone

Question 21

histology of late changes OA
Identify what is 8

Answer 21

thickening of subchondral bone