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UNIT 7 MSK > P3 PHARMACOLOGY > Flashcards

P3 PHARMACOLOGY Flashcards

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1
Q

Rheumatoid arthritis DOC

A

methotrexate

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2
Q

why would you use glucocorticoids

A
  • reduce pain
  • reduce swelling
  • ## slow structural damage progression
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3
Q

what would you use to relieve pain & suppress the inflammation

A

NSAIDS

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4
Q

what would you use to prevent or control joint destruction

A

DMADRS

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5
Q

NSAIDS that have less Gi safety profile

A

Non-selective NSAIDS

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6
Q

NSAIDS that are associated with CV thrombotic events

A

Selective NSAID

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7
Q

Selective NSAIDS contraindications

A

coronary artery disease
by-pass graft surgery

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8
Q

types of DMARDS

A
  • conventional
  • Biological
  • targeted synthetic
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9
Q

Examples of selective NSAIDS

A
  • ibuprofen
  • diclofenac
  • naproxen
  • indomethacin
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10
Q

Examples of non- selective NSAIDS

A

celecoxib , etoricoxib
, valdecoxib

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11
Q

non- selective NSAIDS are co-prescribed with

A

PPI / H2 blockers

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12
Q

give at least 4 ADR OF NSAIDS

A
  • headache
  • asthma
  • rashes
  • renal failure
  • bleeding
  • abdominal pain
  • dysplasia of GIT
  • GIT ulcer
  • fluid retention
  • HTN
  • edmea
  • CHF
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13
Q

subtypes of bDMARDs

A
  • TNf -alpha blocker
  • Non -TNF-alpha blocker
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14
Q

MTX anti-inflammatory effects are mediated by

A

Accumulation of adenosine

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15
Q

MTX ADR can be reduced by

A

leucovorin

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16
Q

MTX side effects

A

Pulmonary fibrosis ,,,, does related hepatotoxicity

17
Q

MOA of MTX

A

Inhibition of dihydrofolate reductase leading to decreased dTMP that leads to decreased DNA synthesis

18
Q

MOA of bDMARDS

A

binds to TNF-alpha in ECF&raquo_space; neutralises it

19
Q

mention the 2 IL-6 blockers

A

sarilumab
tocilizumab

20
Q

Targeted synthetic DMARDs MOA

A

JAK inhibitors

21
Q

MOA OF Rituximab

A

B-cell depleting cytotoxic agent

22
Q

ADR of hydroxychloroquine

A

ocular toxicity

23
Q

MTX ADR

A

myelosuppression, hepatic toxicity , pulmonary infiltrate

24
Q

ADR OF tofacitinib ( JAK Inhibitor )

A

INFECTIONS
dyslipidemia

25
Q

DOC IN DMARD naive patients with low disease activity

A

hydroxychloroquine

26
Q

DOC IN DMARD naive patients with moderate to severe disease activity

A

MTX

27
Q

MOA OF abatacept

A

Inhibitors of T-cell activation by binding to CD80/CD86 thereby blocking CD28 interaction

UNIT 7 MSK (23 decks)

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