P20 - Antiprotozal Flashcards

1
Q

treatment of giardiasis with MOA of DNA damage (3); and which one can be carcinogenic

A
  • metronidazole - can be carcinogenic
  • tinidazole
  • ipronidazole
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2
Q

treatment of giardiasis with MOA of interaction with B-tubulin (2)

A
  • fenbendazole -> prodrug fenbental - 1st choice

- albendazole

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3
Q

treatment of giardiasis with MOA interference with cell membrane (1)

A
  • quinacrine (used for resistant)
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4
Q

treatment of giardiasis with MOA of production of free radicals (1)

A
  • furazolidone
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5
Q

treatment of leishmaniasis 1st line drugs (4)

A
  • allopurinol
  • meglumine antimonate
  • sodium stibogluconate
  • amphotericin B
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6
Q

allopurinol MOA

A
  • prevents uric acid
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7
Q

treatment of leishmaniasis 2nd line drugs (3)

A
  • metronidazole with enrofloxacin
  • paromomycin
  • ketoconazole
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8
Q

paromomycin MOA

A
  • inhibit protein synthesis at 30s
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9
Q

sulphonamides MOA

A
  • inhibition of early steps in folate synthesis
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10
Q

diaminopyrimidines combined with sulphonamides (2)

A
  • trimethoprim

- ormetoprim

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11
Q

treatment of coccidiosis MOA thiamine analogue (2)

A
  • amprolium

- amprolium-sulfadimethoxine

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12
Q

treatment of coccidiosis MOA oxygen free radicals (1)

A
  • furazolidone
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13
Q

treatment of coccidiosis MOA apicoplast interactions (1)

A
  • ponazuril
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14
Q

treatment of coccidiosis MOA folic acid synthesis (2)

A
  • sulfadimethoxine

- trimethoprim-sulfonamide

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15
Q

treatment of coccidiosis that is used in dogs only (1)

A
  • amprolium-sulfadimethoxine
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16
Q

treatment of coccidiosis in chickens

A
  • polyether ionophores
17
Q

polyether ionophores MOA

A
  • form lipophilic complexes with alkali metal cations

- changes in membrane integrity and internal osmolality

18
Q

polyether ionophores drugs (5)

A
  • lasalocid
  • maduramicin
  • monensin
  • narasin
  • salanomycin
19
Q

which polyether ionophores are used in broilers and rearing (2)

A
  • monensin

- salanomycin

20
Q

side effects of polyether ionophores

A
  • cardiovascular effects due to increase Ca
21
Q

highly susceptible species of side effects of polyether ionophores

A
  • equids

- guinea fowl

22
Q

T/F: polyether ionophores can develop resistance

A
  • true
23
Q

drugs against sarcocystis neurona (2)

A
  • triazine derivatives

- nitrothiazole derivatives

24
Q

triazine derivatives MOA

A
  • act on apicoplast
25
Q

triazine derivatives drugs (3)

A
  • diclazuril
  • toltrazuril
  • ponazuril (active metabolite)
26
Q

which triazine derivative due sodium salt increases its bioavability

A
  • diclazuril
27
Q

treatment of piroplasmosis (2)

A
  • imidocarb dipropionate

- naphtoquinones (parvaquone and buparvaquone)

28
Q

which drug is not approved for cattle but is used to treat canine babesiosis

A
  • imidocarb dipropionate
29
Q

which drug is approved for treatment of theilerosis in wild ruminants in the US and domestic in Europe

A
  • naphtoquinones (parvaquone & buparvaquone)