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Pharmacology II > P14 - GI Part 1 > Flashcards

P14 - GI Part 1 Flashcards

1
Q

appetite stimulants MOA

A
  • increase GABA

- decrease serotonin

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2
Q

which appetite stimulant is for cats

A
  • cyproheptadine
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3
Q

appetite stimulant drugs (4)

A
  • benzodiazepines
  • cyptoheptadine
  • glucocorticoids & vit B
  • anabolic steroids
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4
Q

appetite suppressants MOA

A
  • inhibit fat absorption
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5
Q

appetite suppressants drugs (1)

A
  • dirlotapide (Slentrol)
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6
Q

dirlotapide (appetite suppressant) is not used when (2)

A
  • in cats

- in dogs with liver disease, Cushing’s or corticosertoids

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7
Q

5 control centers of emetics (vomiting)

A
  • CTZ
  • vestibular system
  • peripheral sensory
  • neurotransmission from higher CNS
  • substance P
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8
Q

peripherally acting emetics MOA

A
  • irritates mucosa
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9
Q

peripherally acting emetics drugs (3)

A
  • warm salt water
  • hydrogen peroxide
  • ipecac
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10
Q

which peripherally acting emetic due used cautiously in cats

A
  • ipecac
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11
Q

centrally acting emetics MOA

A
  • stimulates CTZ
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12
Q

centrally acting emetics drugs (2) and for what species

A
  • apmonphine hydrochloride - dog

- xylazine - cats

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13
Q

xylazine side effect

A
  • brachycardia
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14
Q

centrally acting anti-emetics groups (4)

A
  • anti-histaminergics
  • anti-muscarinics
  • anti-dopaminergics
  • NK-1 receptor antagonists
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15
Q

centrally acting anti-emetics MOA

A
  • blocks at higher CNS and at emetic center
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16
Q

anti-histaminergics (anti-emetics) MOA

A
  • blocks H1 receptors at vestibular apparatur
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17
Q

anti-histaminergics (anti-emetics) drugs (3)

A
  • cyclizine hydrochloride
  • dimenhydrinate
  • diphenhydramine
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18
Q

anti-histaminergics (anti-emetics) side effects

A
  • sedation
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19
Q

anti-muscarinics (anti-emetics) MOA

A
  • stop M1 and ACh
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20
Q

anti-muscarinics (anti-emetics) drugs (2)

A
  • atropine

- scopolamine

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21
Q

T/F: scopolamine can penetrate the BBB

A
  • true
22
Q

anti-muscarinics (anti-emetics) side effects

A
  • drowsiness
  • constipation
  • urinary retention
23
Q

anti-muscarinics (anti-emetics) used for

A
  • controlling motion sickness in dogs
24
Q

anti-dopaminergics (anti-emetics) MOA

A
  • acting at CTZ
25
Q

anti-dopaminergics (anti-emetics) drugs (4)

A
  • phenothiazine derivatives
  • butyrophenones
  • metoclopramide
  • 5-HT3 serotonin antagonists
26
Q

which anti-dopaminergics (anti-emetics) is broadest spectrum

A
  • phenothiazine derivatives
27
Q

phenothiazine derivatives contra indicated in

A
  • animals with seizures or dehydrated
28
Q

which anti-dopaminergics (anti-emetics) is most potent

A
  • metoclopramide
29
Q

in which species does metoclopramide cause hyperactivity and excitability

A
  • horses and cats
30
Q

which anti-dopaminergics is used for patents on chemo drugs

A
  • ondonsetron
31
Q

NK-1 receptor antagonists MOA

A
  • blocks sup P in CNS
32
Q

NK-1 receptor antagonists (anti-emetics) drugs (1)

A
  • maropitant citrate (cerenia)
33
Q

NK-1 receptor antagonists used for

A
  • motion sickness in dogs
34
Q

side effects of NK-1 receptor antagonists

A
  • bone marrow hypocellularity in young puppies
35
Q

peripherally acting anti-emetics MOA

A
  • protect GI from irritation
36
Q

peripherally acting anti-emetics drugs (3)

A
  • anti-cholinergics
  • metocloprimide
  • domperidone
37
Q

side effects of peripherally acting anti-emetics

A
  • delays gastric emptying
38
Q

group of drugs that decrease gastric acid secretion (4)

A
  • anti-cholinergics
  • H2 receptor antagonist
  • proton pump inhibitors
  • prostaglandin E analogue
39
Q

anti-cholinergics MOA

A
  • acts on M1 receptor
40
Q

anti-cholinergics drug for decrease gastric acid secretion

A
  • pirenzepine
41
Q

H2 receptor antagonists drugs for decreasing gastric acid secretion (4)

A
  • cimetidine
  • ranitidine
  • famotidine
  • nizatidine
42
Q

which H2 receptor antagonist has an immune-modulatory effect (T-cells)

A
  • cimetidine
43
Q

which H2 receptor antagonist is most potent

A
  • famotidine
44
Q

side effects of H2 receptor antagonists that are decreasing gastric acid secretion

A
  • rebound hyperexcretion

- relapse of gastric ulcers

45
Q

T/F: proton pump inhibitors are irreversible

A
  • true
46
Q

proton pump inhibitors drugs for decreasing gastric acid secretion

A
  • omeprazole
47
Q

which class of drugs is aspiration pneumonia in dog with megaesophagous a side effect

A
  • proton pump inhibitors (omeprazole)
48
Q

prostaglandin E analogue MOA

A
  • decrease cAMP -> decreases gastric acid

- increase mucous & bicarb secretion

49
Q

prostaglandin E analogue drug

A
  • misoprostol
50
Q

which drug has no rebound hyperexcretion and is used to decrease gastric acid secretion

A

misoprostol

51
Q

side effects of misoprostol

A
  • diarrhea

- uterine contraction

Pharmacology II (13 decks)

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