P14 - GI Part 1 Flashcards
appetite stimulants MOA
- increase GABA
- decrease serotonin
which appetite stimulant is for cats
- cyproheptadine
appetite stimulant drugs (4)
- benzodiazepines
- cyptoheptadine
- glucocorticoids & vit B
- anabolic steroids
appetite suppressants MOA
- inhibit fat absorption
appetite suppressants drugs (1)
- dirlotapide (Slentrol)
dirlotapide (appetite suppressant) is not used when (2)
- in cats
- in dogs with liver disease, Cushing’s or corticosertoids
5 control centers of emetics (vomiting)
- CTZ
- vestibular system
- peripheral sensory
- neurotransmission from higher CNS
- substance P
peripherally acting emetics MOA
- irritates mucosa
peripherally acting emetics drugs (3)
- warm salt water
- hydrogen peroxide
- ipecac
which peripherally acting emetic due used cautiously in cats
- ipecac
centrally acting emetics MOA
- stimulates CTZ
centrally acting emetics drugs (2) and for what species
- apmonphine hydrochloride - dog
- xylazine - cats
xylazine side effect
- brachycardia
centrally acting anti-emetics groups (4)
- anti-histaminergics
- anti-muscarinics
- anti-dopaminergics
- NK-1 receptor antagonists
centrally acting anti-emetics MOA
- blocks at higher CNS and at emetic center
anti-histaminergics (anti-emetics) MOA
- blocks H1 receptors at vestibular apparatur
anti-histaminergics (anti-emetics) drugs (3)
- cyclizine hydrochloride
- dimenhydrinate
- diphenhydramine
anti-histaminergics (anti-emetics) side effects
- sedation
anti-muscarinics (anti-emetics) MOA
- stop M1 and ACh
anti-muscarinics (anti-emetics) drugs (2)
- atropine
- scopolamine
T/F: scopolamine can penetrate the BBB
- true
anti-muscarinics (anti-emetics) side effects
- drowsiness
- constipation
- urinary retention
anti-muscarinics (anti-emetics) used for
- controlling motion sickness in dogs
anti-dopaminergics (anti-emetics) MOA
- acting at CTZ
anti-dopaminergics (anti-emetics) drugs (4)
- phenothiazine derivatives
- butyrophenones
- metoclopramide
- 5-HT3 serotonin antagonists
which anti-dopaminergics (anti-emetics) is broadest spectrum
- phenothiazine derivatives
phenothiazine derivatives contra indicated in
- animals with seizures or dehydrated
which anti-dopaminergics (anti-emetics) is most potent
- metoclopramide
in which species does metoclopramide cause hyperactivity and excitability
- horses and cats
which anti-dopaminergics is used for patents on chemo drugs
- ondonsetron
NK-1 receptor antagonists MOA
- blocks sup P in CNS
NK-1 receptor antagonists (anti-emetics) drugs (1)
- maropitant citrate (cerenia)
NK-1 receptor antagonists used for
- motion sickness in dogs
side effects of NK-1 receptor antagonists
- bone marrow hypocellularity in young puppies
peripherally acting anti-emetics MOA
- protect GI from irritation
peripherally acting anti-emetics drugs (3)
- anti-cholinergics
- metocloprimide
- domperidone
side effects of peripherally acting anti-emetics
- delays gastric emptying
group of drugs that decrease gastric acid secretion (4)
- anti-cholinergics
- H2 receptor antagonist
- proton pump inhibitors
- prostaglandin E analogue
anti-cholinergics MOA
- acts on M1 receptor
anti-cholinergics drug for decrease gastric acid secretion
- pirenzepine
H2 receptor antagonists drugs for decreasing gastric acid secretion (4)
- cimetidine
- ranitidine
- famotidine
- nizatidine
which H2 receptor antagonist has an immune-modulatory effect (T-cells)
- cimetidine
which H2 receptor antagonist is most potent
- famotidine
side effects of H2 receptor antagonists that are decreasing gastric acid secretion
- rebound hyperexcretion
- relapse of gastric ulcers
T/F: proton pump inhibitors are irreversible
- true
proton pump inhibitors drugs for decreasing gastric acid secretion
- omeprazole
which class of drugs is aspiration pneumonia in dog with megaesophagous a side effect
- proton pump inhibitors (omeprazole)
prostaglandin E analogue MOA
- decrease cAMP -> decreases gastric acid
- increase mucous & bicarb secretion
prostaglandin E analogue drug
- misoprostol
which drug has no rebound hyperexcretion and is used to decrease gastric acid secretion
misoprostol
side effects of misoprostol
- diarrhea
- uterine contraction
