Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology II > P17 - Anticancer > Flashcards

P17 - Anticancer Flashcards

1
Q

cytotoxic drugs MOA

A
  • prevent replication
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

classes of cytotoxic drugs (4)

A
  • alkylating agents
  • antimetabolites
  • cytotoxic antibiotics
  • plant derivatives
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

alkylating agents MOA

A
  • form covalent bonds that cross-link DNA impeding replication
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

alkylating agents side effects

A
  • alopecia
  • bone marrow depletion
  • leukopenia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

platinum analogues drugs (part of alkylating agents) (3)

A
  • cisplatin
  • carboplatin
  • oxaliplaton
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

alkylating agent drugs (7)

A
  • cyclophosphamide
  • melphalan
  • chlorambucil
  • ifosfamide
  • busulfan
  • dacarbazine
  • lomustine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

alkylating agent with lowest chance of toxicity

A
  • chlorambucil
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

alkylating agent that is most potent

A
  • ifosfamide
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

which platinum analogue is a safe alternative for cats

A
  • carboplatin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

antimetabolites MOA

A
  • inhibit production of nucleic acid and proteins for cell division
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

antimetabolites side effects

A
  • GI

- bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

antimetabolites drugs (2)

A
  • methotrexate

- 5-fluorouracil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

is inhibition reversible in antimetabolites

A
  • yes
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

antimetabolite that is not for cats and can cross the BBB

A
  • 5-fluorouracil
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

cytotoxic antibiotics MOA

A
  • binds to DNA and breaks it
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

cytotoxic antibiotics side effects

A
  • necrosis if given outside vein
  • bone marrow
  • GI
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

cytotoxic antibiotics drugs (8)

A
  • actinomycin D
  • dactinomycin
  • antracyclines (doxorubicin)
  • epirubicin
  • danunorubicin
  • idarubicin
  • mitoantrone
  • bleomycin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

cytotoxic antibiotic that causes nephrotoxicity in cats

A
  • antracyclines (doxorubicin)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

cytotoxic antibiotic that has no cardiotoxicity

A
  • epirubicin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

cytotoxic drug that has 25% refractory malignant lymphoma -> remission

A
  • mitoxantrone
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

plant derivatives MOA

A
  • act on microtubules
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

plant derivatives side effects

A
  • GI
  • less bone marrow
  • anaphylactic reactions
23
Q

plant derivatives drug categories (2)

A
  • vinca alkaloids

- taxanes

24
Q

vinca alkaloids drugs (2)

A
  • vincristine

- vinblastine

25
Q

vinca alkaloid are used for what

A
  • TVT
26
Q

taxanes drugs (2)

A
  • paclitaxel

- docetaxel

27
Q

what should you use to pretreat when using taxanes

A
  • glucocorticoids or antihistamines
28
Q

L-asparaginase MOA

A
  • inhibits protein synthesis
29
Q

L-asparaginase side effects

A
  • hypersensitivity

- pancreatitis

30
Q

what can some tumors produce, making this drug not useful

A
  • L-asparaginase
31
Q

immune therapies MOA

A
  • directly acting on cell or against microenvironment
32
Q

classes of immune therapies (5)

A
  • monoclonal antibodies
  • transfer of T-cells
  • therapeutic vac.
  • cytokine therapies
  • modulation of immune signaling
33
Q

monoclonal antibodies MOA

A
  • protein kinase inhibitors
34
Q

monoclonal antibodies drugs (end in…)

A
  • end in (-mab)
35
Q

majority of monoclonal antibodies receptors require _____ of intracellular signaling

A
  • phosphorylation
36
Q

tyrosine kinase inhibitors MOA

A
  • block kinase receptor in cell
37
Q

tyrosine kinase drugs (end in…)

A
  • end in (-nib)
38
Q

do monoclonal antibodies or tyrosine kinase drugs work better

A
  • tyrosine kinase
39
Q

modulation of immune signaling by 2 things

A
  • bacilli calmetter guerin (BCG)

- imiquimod

40
Q

bacilli calmetter guerin (BCG) MOA

A
  • stimulating alveolar macrophages and promote lymphocyte cytotoxicity
41
Q

bacilli calmetter guerin (BCG) side effects

A
  • granulomas

- anaphylaxis

42
Q

imiquimod MOA

A
  • immune response around tumor
43
Q

imiquimod regulated by what toll-like receptor

A
  • TLR-7
44
Q

selective inhibitors of nuclear transport MOA

A
  • makes cell function normally -> apoptosis
45
Q

selective inhibitors of nuclear transport drugs (2)

A
  • selinexor

- verdinexor

46
Q

selective inhibitors of nuclear transport inhibit what

A
  • XPO-1
47
Q

heat shock proteins are also known as

A
  • chaperoins
48
Q

heat shock proteins MOA

A
  • inhibit HSP 90 -> stop tumor growth
49
Q

heat shock proteins drugs (1)

A
  • ganetespib
50
Q

steroid hormones and antagonists categories (4)

A
  • glucocorticoids
  • anti-androgens
  • anti-estrogens
  • anti-prostagens
51
Q

which steroid hormones and antagonist manage secondary complications

A
  • glucocorticoids
52
Q

which steroid hormones and antagonist is used for perinanal gland tumors

A
  • anti-andogrens (Delmadinone)
53
Q

which steroid hormones and antagonist is used for mammary carcinomas

A
  • anti-estrogens (tamoxifen)
54
Q

which steroid hormones and antagonist is used for mammary tumors

A
  • anti-prostagens

Pharmacology II (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions