P15 - GI Part 2 Flashcards
cytoprotective drugs classes (4)
- antacids
- prostaglandin E1 analog
- sucralfate
- bismuth subsalicylate
antacids MOA
- bases that react with HCL -> insoluble colloid & H2O
non-systemic antacids drugs (2)
- aluminum hydroxide
- magnesium hydroxide
systemic antacids drugs (1)
- sodium bicarbonate
side effect of sodium bicarbonate
- bloat
prostaglandin E1 analog MOA
- increase mucus & bicarb
- stabilizes mast cells
prostaglandin E1 analog drugs
- misoprostol
sucralfate MOA
- protect ulcer tissue from acid, bile and pepsin
side effects of sucralfate
- decreases oral bioavability of other drugs
sucralfate requires what type of environment
- acidic
bismuth MOA
- absorbs E. coli entertoxins
salicylate MOA
- decrease intestinal secretions
- anti-inflammatory
salicylate is used cautiously in what species and why
- cats
- glucorconidation
classes of drugs that increase GI motility (2)
- cholinergic agonists
- prokinetic agents
cholinergic agonists MOA
- agonist on ACh receptors
- for GI muscle atony
cholinergic agonists drugs (2)
- bethanechol
- carbachol
cholinergic agonists side effects
- cramps
- diarrhea
- salivation
- bradycardia
cholinergic agonists are contra indicated for
- obstructions
- peritonitis
prokinetic agents MOA
- increase ACh
- block dopamine
prokinetic agents drugs (3)
- metoclopramide
- cisapride
- domperidone
cisapride spectrum and specific use
- broad spectrum
- for megacolon in cats
classes of drugs that decrease intestinal motility and secretions (2)
- anti-cholinergics
- opioid agonists
anti-cholinergics MOA
- inhibit ACh
anti-cholinergics drugs (2)
- atropine
- scopolamine
clinical indications of anti-cholinergic drugs
- diarrhea in calves
- mild colic
anti-cholinergics combined with NSAIDs effect
- clear smooth muscle spasm
opioid agonists MOA -
- inhibit ACh and choline receptors
opioid drugs (4)
- morphine
- fentanyl
- meperidine
- paregotic
meperidine drugs (2)
- diphenoxylate (difenoxin)
- loperamide
cat that ODs on diphenoxylate signs
- neurological signs
paregotic is used in what species
- foals
opioid agonists are indicated for what
- non-specific acute & chronic diarrhea
opioid agonists are contra indicated for what
- diarrhea due to infectious causes
anti-diarrheal drugs for cats
- propantheline
- loperamide hydrochloride caspsules
- bismuth subsalicylate suspension
GI protectants and absorbents MOA
- line GI and precent irritation
GI protectants and absorbents drug
- bismuth subsalicylate
- activated charcoal
- cholestyramine
- kaolin
- pectin
bismuth subsalicylate absorbs
- E. coli enterotoxins
activated charcoal is used for
- emergency treatment
cholestyramine is used for
- hyperchotesterolemia
side effects of cholestyramine
- nausea
- constipation
- decrease absorption of fat soluble vitamins
kaolin and pectin are used for
- non-specific diarrhea
