P15 - GI Part 2 Flashcards

1
Q

cytoprotective drugs classes (4)

A
  • antacids
  • prostaglandin E1 analog
  • sucralfate
  • bismuth subsalicylate
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2
Q

antacids MOA

A
  • bases that react with HCL -> insoluble colloid & H2O
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3
Q

non-systemic antacids drugs (2)

A
  • aluminum hydroxide

- magnesium hydroxide

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4
Q

systemic antacids drugs (1)

A
  • sodium bicarbonate
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5
Q

side effect of sodium bicarbonate

A
  • bloat
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6
Q

prostaglandin E1 analog MOA

A
  • increase mucus & bicarb

- stabilizes mast cells

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7
Q

prostaglandin E1 analog drugs

A
  • misoprostol
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8
Q

sucralfate MOA

A
  • protect ulcer tissue from acid, bile and pepsin
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9
Q

side effects of sucralfate

A
  • decreases oral bioavability of other drugs
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10
Q

sucralfate requires what type of environment

A
  • acidic
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11
Q

bismuth MOA

A
  • absorbs E. coli entertoxins
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12
Q

salicylate MOA

A
  • decrease intestinal secretions

- anti-inflammatory

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13
Q

salicylate is used cautiously in what species and why

A
  • cats

- glucorconidation

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14
Q

classes of drugs that increase GI motility (2)

A
  • cholinergic agonists

- prokinetic agents

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15
Q

cholinergic agonists MOA

A
  • agonist on ACh receptors

- for GI muscle atony

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16
Q

cholinergic agonists drugs (2)

A
  • bethanechol

- carbachol

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17
Q

cholinergic agonists side effects

A
  • cramps
  • diarrhea
  • salivation
  • bradycardia
18
Q

cholinergic agonists are contra indicated for

A
  • obstructions

- peritonitis

19
Q

prokinetic agents MOA

A
  • increase ACh

- block dopamine

20
Q

prokinetic agents drugs (3)

A
  • metoclopramide
  • cisapride
  • domperidone
21
Q

cisapride spectrum and specific use

A
  • broad spectrum

- for megacolon in cats

22
Q

classes of drugs that decrease intestinal motility and secretions (2)

A
  • anti-cholinergics

- opioid agonists

23
Q

anti-cholinergics MOA

A
  • inhibit ACh
24
Q

anti-cholinergics drugs (2)

A
  • atropine

- scopolamine

25
Q

clinical indications of anti-cholinergic drugs

A
  • diarrhea in calves

- mild colic

26
Q

anti-cholinergics combined with NSAIDs effect

A
  • clear smooth muscle spasm
27
Q

opioid agonists MOA -

A
  • inhibit ACh and choline receptors
28
Q

opioid drugs (4)

A
  • morphine
  • fentanyl
  • meperidine
  • paregotic
29
Q

meperidine drugs (2)

A
  • diphenoxylate (difenoxin)

- loperamide

30
Q

cat that ODs on diphenoxylate signs

A
  • neurological signs
31
Q

paregotic is used in what species

A
  • foals
32
Q

opioid agonists are indicated for what

A
  • non-specific acute & chronic diarrhea
33
Q

opioid agonists are contra indicated for what

A
  • diarrhea due to infectious causes
34
Q

anti-diarrheal drugs for cats

A
  • propantheline
  • loperamide hydrochloride caspsules
  • bismuth subsalicylate suspension
35
Q

GI protectants and absorbents MOA

A
  • line GI and precent irritation
36
Q

GI protectants and absorbents drug

A
  • bismuth subsalicylate
  • activated charcoal
  • cholestyramine
  • kaolin
  • pectin
37
Q

bismuth subsalicylate absorbs

A
  • E. coli enterotoxins
38
Q

activated charcoal is used for

A
  • emergency treatment
39
Q

cholestyramine is used for

A
  • hyperchotesterolemia
40
Q

side effects of cholestyramine

A
  • nausea
  • constipation
  • decrease absorption of fat soluble vitamins
41
Q

kaolin and pectin are used for

A
  • non-specific diarrhea