Oxygen-hemglobin dissociation curve Flashcards
1
Q
Why sigmoidal
A
Positive cooperativity (tetrameric hemoglobin, higher affinity for each subsequent oxygen molecule bound)
2
Q
Myoglobin
A
monomeric and thus does not show cooperativity;
curve lacks sigmoidal appearance.
3
Q
Right shift
A
low affinity for O2
4
Q
Causes of right shift
A
Increase in all of the factors: "C-BEAT" CO2 BPG (2,3-BPG) Exercise Acid/altitude Temperature.
Left shift; desase of all
5
Q
Fetal Hb
A
Higher affinity for O2 than adult Hb,
so its dissociation curve shifted left.
